Chromatin effector Pygo2 regulates mammary tumor initiation and heterogeneity in MMTV-Wnt1 mice

Little is known about chromatin mechanisms that regulate tumor-initiating cells that are proposed to be responsible for tumor recurrence and relapse. We have previously shown that Pygopus 2 (Pygo2), a chromatin effector and context-dependent Wnt signaling coactivator, regulates mammary gland develop...

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Veröffentlicht in:	Oncogene 2014-01, Vol.33 (5), p.632-642
Hauptverfasser:	Watanabe, K, Fallahi, M, Dai, X
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/2329 631/67/395 631/80/86 692/699/67/1347 Animals Anthelmintics - pharmacology Apoptosis Breast cancer Breast tumors Cell Biology Cell Transformation, Neoplastic - genetics Chromatin Chromatin - genetics Female Genetic aspects Genetic regulation Genetic Variation Health aspects Human Genetics Internal Medicine Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Male Mammary Glands, Animal - growth & development Mammary Glands, Animal - metabolism Mammary Glands, Animal - virology Mammary Neoplasms, Animal - genetics Mammary Neoplasms, Animal - metabolism Mammary Neoplasms, Animal - virology Mammary Tumor Virus, Mouse - genetics Medicine Medicine & Public Health Mice Mice, Transgenic Neoplastic Stem Cells - cytology Oncology original-article Pyrvinium Compounds - pharmacology RNA Interference RNA, Small Interfering Stem cells Studies Tumor Cells, Cultured Tumors Wnt Signaling Pathway - drug effects Wnt Signaling Pathway - genetics Wnt1 Protein - antagonists & inhibitors Wnt1 Protein - genetics
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