Comparision of uroprotective activity of reduced glutathione with Mesna in Ifosfamide induced hemorrhagic cystitis in rats

Background: Ifosfamide (IFO) is widely used DNA-alkylating agents in cancer chemotherapy for management of solid tumors and hematological malignancies. However, hemorrhagic cystitis limits the use of IFO. Objectives: To compare the efficiency of reduced glutathione with 2-Mesna in reducing Ifosfamid...

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Veröffentlicht in:	Indian journal of pharmacology 2014-01, Vol.46 (1), p.105-108
Hauptverfasser:	Ali, Syed, Danda, Sandeep, Basha, Syed Abdul, Rasheed, Asif, Ahmed, Osman, Ahmed, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Alkylating - adverse effects Chemotherapy Complications and side effects Cystitis Cystitis - chemically induced Cystitis - prevention & control Drug interactions Drug therapy Glutathione Glutathione - pharmacology Health aspects Hemorrhage - chemically induced Hemorrhage - prevention & control Ifosfamide Ifosfamide - adverse effects Mesna - adverse effects Pharmaceutical research Pharmacology Physiological aspects Protective Agents - adverse effects Rats Rats, Wistar Rodents Urinary Bladder - drug effects Urinary Bladder - pathology
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