Neurotoxicants Are in the Air : Convergence of Human, Animal, and In Vitro Studies on the Effects of Air Pollution on the Brain
In addition to increased morbidity and mortality caused by respiratory and cardiovascular diseases, air pollution may also negatively affect the brain and contribute to central nervous system diseases. Air pollution is a mixture comprised of several components, of which ultrafine particulate matter...
Gespeichert in:
| Veröffentlicht in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-8 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 8 |
|---|---|
| container_issue | 2014 |
| container_start_page | 1 |
| container_title | BioMed research international |
| container_volume | 2014 |
| creator | Costa, Lucio Guido Cole, Toby B. Coburn, Jacki Chang, Yu-Chi Dao, Khoi Roque, Pamela |
| description | In addition to increased morbidity and mortality caused by respiratory and cardiovascular diseases, air pollution may also negatively affect the brain and contribute to central nervous system diseases. Air pollution is a mixture comprised of several components, of which ultrafine particulate matter (UFPM; |
| doi_str_mv | 10.1155/2014/736385 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3912642</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A427024276</galeid><sourcerecordid>A427024276</sourcerecordid><originalsourceid>FETCH-LOGICAL-c490t-8e3a5694f0f4bc70752ed73a9a018ad542246e798bac0150efda2969e7f18e1d3</originalsourceid><addsrcrecordid>eNqFkktv1DAQgCMEolXpiTPIEhcEXep3Yg5IYVVopQqQeFwtrzPedZW1WzspcOKv4yjL8rjgg21pvvnGI09VPST4BSFCnFJM-GnNJGvEneqQMsIXknByd39n7KA6zvkKl9UQiZW8Xx1QLijHjTysfryDMcUhfvPWhCGjNgHyAQ0bQK1P6CVaxnALaQ3BAooOnY9bE05QG_zW9CfIhA5dBPTFDymij8PYecgozvlnzoEtypI1qT7Evh8HX4K7-OtkfHhQ3XOmz3C8O4-qz2_OPi3PF5fv314s28uF5QoPiwaYEVJxhx1f2RrXgkJXM6MMJo3pBKeUS6hVszIWE4HBdYYqqaB2pAHSsaPq1ey9Hldb6CyEIZleX6fSR_quo_H670jwG72Ot5opQiWnRfB0J0jxZoQ86K3PFvreBIhj1kQw3lAiGlnQJ_-gV3FMobRXKMxkIRX9Ta1ND9oHF0tdO0l1y2mNadkm1_OZsinmnMDtn0ywniZATxOg5wko9OM_u9yzv_67AM9mYONDZ776_9gezTAUBJzZw1xxoQT7CThjv3s</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1503653492</pqid></control><display><type>article</type><title>Neurotoxicants Are in the Air : Convergence of Human, Animal, and In Vitro Studies on the Effects of Air Pollution on the Brain</title><source>MEDLINE</source><source>Wiley-Blackwell Open Access Titles</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Costa, Lucio Guido ; Cole, Toby B. ; Coburn, Jacki ; Chang, Yu-Chi ; Dao, Khoi ; Roque, Pamela</creator><contributor>Bale, Ambuja</contributor><creatorcontrib>Costa, Lucio Guido ; Cole, Toby B. ; Coburn, Jacki ; Chang, Yu-Chi ; Dao, Khoi ; Roque, Pamela ; Bale, Ambuja</creatorcontrib><description>In addition to increased morbidity and mortality caused by respiratory and cardiovascular diseases, air pollution may also negatively affect the brain and contribute to central nervous system diseases. Air pollution is a mixture comprised of several components, of which ultrafine particulate matter (UFPM; <100 nm) is of much concern, as these particles can enter the circulation and distribute to most organs, including the brain. A major constituent of ambient UFPM is represented by traffic-related air pollution, mostly ascribed to diesel exhaust (DE). Human epidemiological studies and controlled animal studies have shown that exposure to air pollution may lead to neurotoxicity. In addition to a variety of behavioral abnormalities, two prominent effects caused by air pollution are oxidative stress and neuroinflammation, which are seen in both humans and animals and are confirmed by in vitro studies. Among factors which can affect neurotoxic outcomes, age is considered the most relevant. Human and animal studies suggest that air pollution (and DE) may cause developmental neurotoxicity and may contribute to the etiology of neurodevelopmental disorders, including autistic spectrum disorders. In addition, air pollution exposure has been associated with increased expression of markers of neurodegenerative disease pathologies.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/736385</identifier><identifier>PMID: 24524086</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Air Pollutants - analysis ; Air Pollutants - toxicity ; Air pollution ; Animal cognition ; Animals ; Biomedical Research ; Brain ; Brain - drug effects ; Brain research ; Cell Line ; Central nervous system diseases ; Colleges & universities ; Convergence ; Dogs ; Environmental aspects ; Health aspects ; Health sciences ; Humans ; Mice ; Mortality ; Neurotoxic agents ; Neurotoxicity ; Neurotoxins - analysis ; Neurotoxins - toxicity ; Oxidative stress ; Rats ; Review ; Rodents ; Toxicity ; Toxicity Tests</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-8</ispartof><rights>Copyright © 2014 Lucio G. Costa et al.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 Lucio G. Costa et al. Lucio G. Costa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Lucio G. Costa et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-8e3a5694f0f4bc70752ed73a9a018ad542246e798bac0150efda2969e7f18e1d3</citedby><cites>FETCH-LOGICAL-c490t-8e3a5694f0f4bc70752ed73a9a018ad542246e798bac0150efda2969e7f18e1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912642/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912642/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24524086$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bale, Ambuja</contributor><creatorcontrib>Costa, Lucio Guido</creatorcontrib><creatorcontrib>Cole, Toby B.</creatorcontrib><creatorcontrib>Coburn, Jacki</creatorcontrib><creatorcontrib>Chang, Yu-Chi</creatorcontrib><creatorcontrib>Dao, Khoi</creatorcontrib><creatorcontrib>Roque, Pamela</creatorcontrib><title>Neurotoxicants Are in the Air : Convergence of Human, Animal, and In Vitro Studies on the Effects of Air Pollution on the Brain</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>In addition to increased morbidity and mortality caused by respiratory and cardiovascular diseases, air pollution may also negatively affect the brain and contribute to central nervous system diseases. Air pollution is a mixture comprised of several components, of which ultrafine particulate matter (UFPM; <100 nm) is of much concern, as these particles can enter the circulation and distribute to most organs, including the brain. A major constituent of ambient UFPM is represented by traffic-related air pollution, mostly ascribed to diesel exhaust (DE). Human epidemiological studies and controlled animal studies have shown that exposure to air pollution may lead to neurotoxicity. In addition to a variety of behavioral abnormalities, two prominent effects caused by air pollution are oxidative stress and neuroinflammation, which are seen in both humans and animals and are confirmed by in vitro studies. Among factors which can affect neurotoxic outcomes, age is considered the most relevant. Human and animal studies suggest that air pollution (and DE) may cause developmental neurotoxicity and may contribute to the etiology of neurodevelopmental disorders, including autistic spectrum disorders. In addition, air pollution exposure has been associated with increased expression of markers of neurodegenerative disease pathologies.</description><subject>Air Pollutants - analysis</subject><subject>Air Pollutants - toxicity</subject><subject>Air pollution</subject><subject>Animal cognition</subject><subject>Animals</subject><subject>Biomedical Research</subject><subject>Brain</subject><subject>Brain - drug effects</subject><subject>Brain research</subject><subject>Cell Line</subject><subject>Central nervous system diseases</subject><subject>Colleges & universities</subject><subject>Convergence</subject><subject>Dogs</subject><subject>Environmental aspects</subject><subject>Health aspects</subject><subject>Health sciences</subject><subject>Humans</subject><subject>Mice</subject><subject>Mortality</subject><subject>Neurotoxic agents</subject><subject>Neurotoxicity</subject><subject>Neurotoxins - analysis</subject><subject>Neurotoxins - toxicity</subject><subject>Oxidative stress</subject><subject>Rats</subject><subject>Review</subject><subject>Rodents</subject><subject>Toxicity</subject><subject>Toxicity Tests</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkktv1DAQgCMEolXpiTPIEhcEXep3Yg5IYVVopQqQeFwtrzPedZW1WzspcOKv4yjL8rjgg21pvvnGI09VPST4BSFCnFJM-GnNJGvEneqQMsIXknByd39n7KA6zvkKl9UQiZW8Xx1QLijHjTysfryDMcUhfvPWhCGjNgHyAQ0bQK1P6CVaxnALaQ3BAooOnY9bE05QG_zW9CfIhA5dBPTFDymij8PYecgozvlnzoEtypI1qT7Evh8HX4K7-OtkfHhQ3XOmz3C8O4-qz2_OPi3PF5fv314s28uF5QoPiwaYEVJxhx1f2RrXgkJXM6MMJo3pBKeUS6hVszIWE4HBdYYqqaB2pAHSsaPq1ey9Hldb6CyEIZleX6fSR_quo_H670jwG72Ot5opQiWnRfB0J0jxZoQ86K3PFvreBIhj1kQw3lAiGlnQJ_-gV3FMobRXKMxkIRX9Ta1ND9oHF0tdO0l1y2mNadkm1_OZsinmnMDtn0ywniZATxOg5wko9OM_u9yzv_67AM9mYONDZ776_9gezTAUBJzZw1xxoQT7CThjv3s</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Costa, Lucio Guido</creator><creator>Cole, Toby B.</creator><creator>Coburn, Jacki</creator><creator>Chang, Yu-Chi</creator><creator>Dao, Khoi</creator><creator>Roque, Pamela</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T2</scope><scope>7TV</scope><scope>7U2</scope><scope>5PM</scope></search><sort><creationdate>20140101</creationdate><title>Neurotoxicants Are in the Air : Convergence of Human, Animal, and In Vitro Studies on the Effects of Air Pollution on the Brain</title><author>Costa, Lucio Guido ; Cole, Toby B. ; Coburn, Jacki ; Chang, Yu-Chi ; Dao, Khoi ; Roque, Pamela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-8e3a5694f0f4bc70752ed73a9a018ad542246e798bac0150efda2969e7f18e1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Air Pollutants - analysis</topic><topic>Air Pollutants - toxicity</topic><topic>Air pollution</topic><topic>Animal cognition</topic><topic>Animals</topic><topic>Biomedical Research</topic><topic>Brain</topic><topic>Brain - drug effects</topic><topic>Brain research</topic><topic>Cell Line</topic><topic>Central nervous system diseases</topic><topic>Colleges & universities</topic><topic>Convergence</topic><topic>Dogs</topic><topic>Environmental aspects</topic><topic>Health aspects</topic><topic>Health sciences</topic><topic>Humans</topic><topic>Mice</topic><topic>Mortality</topic><topic>Neurotoxic agents</topic><topic>Neurotoxicity</topic><topic>Neurotoxins - analysis</topic><topic>Neurotoxins - toxicity</topic><topic>Oxidative stress</topic><topic>Rats</topic><topic>Review</topic><topic>Rodents</topic><topic>Toxicity</topic><topic>Toxicity Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Costa, Lucio Guido</creatorcontrib><creatorcontrib>Cole, Toby B.</creatorcontrib><creatorcontrib>Coburn, Jacki</creatorcontrib><creatorcontrib>Chang, Yu-Chi</creatorcontrib><creatorcontrib>Dao, Khoi</creatorcontrib><creatorcontrib>Roque, Pamela</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Pollution Abstracts</collection><collection>Safety Science and Risk</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Costa, Lucio Guido</au><au>Cole, Toby B.</au><au>Coburn, Jacki</au><au>Chang, Yu-Chi</au><au>Dao, Khoi</au><au>Roque, Pamela</au><au>Bale, Ambuja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurotoxicants Are in the Air : Convergence of Human, Animal, and In Vitro Studies on the Effects of Air Pollution on the Brain</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2014</volume><issue>2014</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>In addition to increased morbidity and mortality caused by respiratory and cardiovascular diseases, air pollution may also negatively affect the brain and contribute to central nervous system diseases. Air pollution is a mixture comprised of several components, of which ultrafine particulate matter (UFPM; <100 nm) is of much concern, as these particles can enter the circulation and distribute to most organs, including the brain. A major constituent of ambient UFPM is represented by traffic-related air pollution, mostly ascribed to diesel exhaust (DE). Human epidemiological studies and controlled animal studies have shown that exposure to air pollution may lead to neurotoxicity. In addition to a variety of behavioral abnormalities, two prominent effects caused by air pollution are oxidative stress and neuroinflammation, which are seen in both humans and animals and are confirmed by in vitro studies. Among factors which can affect neurotoxic outcomes, age is considered the most relevant. Human and animal studies suggest that air pollution (and DE) may cause developmental neurotoxicity and may contribute to the etiology of neurodevelopmental disorders, including autistic spectrum disorders. In addition, air pollution exposure has been associated with increased expression of markers of neurodegenerative disease pathologies.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>24524086</pmid><doi>10.1155/2014/736385</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2314-6133 |
| ispartof | BioMed research international, 2014-01, Vol.2014 (2014), p.1-8 |
| issn | 2314-6133 2314-6141 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3912642 |
| source | MEDLINE; Wiley-Blackwell Open Access Titles; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Air Pollutants - analysis Air Pollutants - toxicity Air pollution Animal cognition Animals Biomedical Research Brain Brain - drug effects Brain research Cell Line Central nervous system diseases Colleges & universities Convergence Dogs Environmental aspects Health aspects Health sciences Humans Mice Mortality Neurotoxic agents Neurotoxicity Neurotoxins - analysis Neurotoxins - toxicity Oxidative stress Rats Review Rodents Toxicity Toxicity Tests |
| title | Neurotoxicants Are in the Air : Convergence of Human, Animal, and In Vitro Studies on the Effects of Air Pollution on the Brain |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T02%3A24%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neurotoxicants%20Are%20in%20the%20Air%20:%20Convergence%20of%20Human,%20Animal,%20and%20In%20Vitro%20Studies%20on%20the%20Effects%20of%20Air%20Pollution%20on%20the%20Brain&rft.jtitle=BioMed%20research%20international&rft.au=Costa,%20Lucio%20Guido&rft.date=2014-01-01&rft.volume=2014&rft.issue=2014&rft.spage=1&rft.epage=8&rft.pages=1-8&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2014/736385&rft_dat=%3Cgale_pubme%3EA427024276%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1503653492&rft_id=info:pmid/24524086&rft_galeid=A427024276&rfr_iscdi=true |