Impact of Potential Permissive Neuraminidase Mutations on Viral Fitness of the H275Y Oseltamivir-Resistant Influenza A(H1N1)pdm09 Virus In Vitro, in Mice and in Ferrets
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| Veröffentlicht in: | Journal of Virology 2014-02, Vol.88 (3), p.1652-1658 |
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| container_title | Journal of Virology |
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| creator | Abed, Yacine Pizzorno, Andrés Bouhy, Xavier Rhéaume, Chantal Boivin, Guy |
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| doi_str_mv | 10.1128/JVI.02681-13 |
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</description><identifier>ISSN: 0022-538X</identifier><identifier>EISSN: 1098-5514</identifier><identifier>DOI: 10.1128/JVI.02681-13</identifier><identifier>PMID: 24257597</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Amino Acid Motifs ; Animals ; Antiviral Agents - pharmacology ; Drug Resistance, Viral ; Female ; Ferrets ; Humans ; Influenza A Virus, H1N1 Subtype - enzymology ; Influenza A Virus, H1N1 Subtype - genetics ; Influenza A Virus, H1N1 Subtype - pathogenicity ; Influenza A Virus, H1N1 Subtype - physiology ; Influenza, Human - mortality ; Influenza, Human - transmission ; Influenza, Human - virology ; Male ; Mice ; Mice, Inbred C57BL ; Mustela ; Mutation, Missense ; Neuraminidase - chemistry ; Neuraminidase - genetics ; Neuraminidase - metabolism ; Oseltamivir - pharmacology ; Vaccines and Antiviral Agents ; Viral Proteins - chemistry ; Viral Proteins - genetics ; Viral Proteins - metabolism ; Virulence ; Virus Replication</subject><ispartof>Journal of Virology, 2014-02, Vol.88 (3), p.1652-1658</ispartof><rights>Copyright © 2014, American Society for Microbiology. All Rights Reserved. 2014 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-c356c94ec8466529646a726b8116d84848d77f99edba779f8d4a30d39a7704213</citedby><cites>FETCH-LOGICAL-c405t-c356c94ec8466529646a726b8116d84848d77f99edba779f8d4a30d39a7704213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911590/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911590/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24257597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abed, Yacine</creatorcontrib><creatorcontrib>Pizzorno, Andrés</creatorcontrib><creatorcontrib>Bouhy, Xavier</creatorcontrib><creatorcontrib>Rhéaume, Chantal</creatorcontrib><creatorcontrib>Boivin, Guy</creatorcontrib><title>Impact of Potential Permissive Neuraminidase Mutations on Viral Fitness of the H275Y Oseltamivir-Resistant Influenza A(H1N1)pdm09 Virus In Vitro, in Mice and in Ferrets</title><title>Journal of Virology</title><addtitle>J Virol</addtitle><description>Classifications
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</description><subject>Amino Acid Motifs</subject><subject>Animals</subject><subject>Antiviral Agents - pharmacology</subject><subject>Drug Resistance, Viral</subject><subject>Female</subject><subject>Ferrets</subject><subject>Humans</subject><subject>Influenza A Virus, H1N1 Subtype - enzymology</subject><subject>Influenza A Virus, H1N1 Subtype - genetics</subject><subject>Influenza A Virus, H1N1 Subtype - pathogenicity</subject><subject>Influenza A Virus, H1N1 Subtype - physiology</subject><subject>Influenza, Human - mortality</subject><subject>Influenza, Human - transmission</subject><subject>Influenza, Human - virology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mustela</subject><subject>Mutation, Missense</subject><subject>Neuraminidase - chemistry</subject><subject>Neuraminidase - genetics</subject><subject>Neuraminidase - metabolism</subject><subject>Oseltamivir - pharmacology</subject><subject>Vaccines and Antiviral Agents</subject><subject>Viral Proteins - chemistry</subject><subject>Viral Proteins - genetics</subject><subject>Viral Proteins - metabolism</subject><subject>Virulence</subject><subject>Virus Replication</subject><issn>0022-538X</issn><issn>1098-5514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkktv1DAUhSMEotPCjjUyuyI1xe_YG6SqYphBfQlBBSvLk9x0XCXOYDtTwS_iZ-IwpYId8sLXup-PfI9PUbwg-JgQqt58uF4eYyoVKQl7VMwI1qoUgvDHxQxjSkvB1Je9Yj_GW4wJ55I_LfYop6ISupoVP5f9xtYJDS26GhL45GyHriD0Lka3BXQBY7C9866xEdD5mGxyg49o8OjahczOXfIQ4ySQ1oAWtBJf0WWELuVrWxfKjxBdTNYntPRtN4L_YdHJ4YJckNebpsd60hljbuYiheEIOY_OXQ3I-maq5xACpPiseNLaLsLz-_2g-Dx_9-l0UZ5dvl-enpyVNccilTUTstYcasWlFFRLLm1F5UoRIhvF82qqqtUampWtKt2qhluGG6bzCXNK2EHxdqe7GVc9NHW2JI9pNsH1Nnw3g3Xm3453a3MzbA3ThAiNs8DhvUAYvo0Qk8le1tB11sMwRkO4lkpLKf8LxVXFmGYZPdqhdRhiDNA-vIhgM-XA5ByY3zkwZMJf_j3FA_zn4zPwages3c36zgUwNvbmduuMUoYZkr1jvwAW2rl4</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Abed, Yacine</creator><creator>Pizzorno, Andrés</creator><creator>Bouhy, Xavier</creator><creator>Rhéaume, Chantal</creator><creator>Boivin, Guy</creator><general>American Society for Microbiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20140201</creationdate><title>Impact of Potential Permissive Neuraminidase Mutations on Viral Fitness of the H275Y Oseltamivir-Resistant Influenza A(H1N1)pdm09 Virus In Vitro, in Mice and in Ferrets</title><author>Abed, Yacine ; 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</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>24257597</pmid><doi>10.1128/JVI.02681-13</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Virology, 2014-02, Vol.88 (3), p.1652-1658 |
| issn | 0022-538X 1098-5514 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3911590 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Amino Acid Motifs Animals Antiviral Agents - pharmacology Drug Resistance, Viral Female Ferrets Humans Influenza A Virus, H1N1 Subtype - enzymology Influenza A Virus, H1N1 Subtype - genetics Influenza A Virus, H1N1 Subtype - pathogenicity Influenza A Virus, H1N1 Subtype - physiology Influenza, Human - mortality Influenza, Human - transmission Influenza, Human - virology Male Mice Mice, Inbred C57BL Mustela Mutation, Missense Neuraminidase - chemistry Neuraminidase - genetics Neuraminidase - metabolism Oseltamivir - pharmacology Vaccines and Antiviral Agents Viral Proteins - chemistry Viral Proteins - genetics Viral Proteins - metabolism Virulence Virus Replication |
| title | Impact of Potential Permissive Neuraminidase Mutations on Viral Fitness of the H275Y Oseltamivir-Resistant Influenza A(H1N1)pdm09 Virus In Vitro, in Mice and in Ferrets |
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