Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition

Multiple genetic variants of CARD15/NOD2 have been associated with susceptibility to Crohn's disease and Blau syndrome. NOD2 recognizes muramyl dipeptide (MDP) derived from bacterial peptidoglycan (PGN), but the molecular basis of recognition remains elusive. We performed systematic mutational...

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Veröffentlicht in:	The EMBO journal 2004-04, Vol.23 (7), p.1587-1597
Hauptverfasser:	Tanabe, Tsuyoshi, Chamaillard, Mathias, Ogura, Yasunori, Zhu, Li, Qiu, Su, Masumoto, Junya, Ghosh, Partho, Moran, Anthony, Predergast, Martina M, Tromp, Gerard, Williams, Charlene J, Inohara, Naohiro, Núñez, Gabriel
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylmuramyl-Alanyl-Isoglutamine - metabolism Amino Acid Sequence Bacteria - metabolism Cell Line DNA Mutational Analysis EMBO24 EMBO37 Genetic Predisposition to Disease Genetic variance Humans Intracellular Signaling Peptides and Proteins - chemistry Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Models, Molecular Molecular Sequence Data Mutation Nod2 Signaling Adaptor Protein Point Mutation Protein Structure, Tertiary Residues Signal Transduction - physiology
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