The myxobacterial metabolite ratjadone A inhibits HIV infection by blocking the Rev/CRM1-mediated nuclear export pathway

The nuclear export of unspliced and partially spliced HIV-1 mRNA is mediated by the recognition of a leucine-rich nuclear export signal (NES) in the HIV Rev protein by the host protein CRM1/Exportin1. This makes the CRM1-Rev complex an attractive target for the development of new antiviral drugs. He...

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Veröffentlicht in:	Microbial cell factories 2014-01, Vol.13 (1), p.17-17, Article 17
Hauptverfasser:	Fleta-Soriano, Eric, Martinez, Javier P, Hinkelmann, Bettina, Gerth, Klaus, Washausen, Peter, Diez, Juana, Frank, Ronald, Sasse, Florenz, Meyerhans, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects Antiviral Agents - pharmacology Cell Line CRM1 Cytoplasm Drug dosages Drug therapy Exportin 1 Protein Exports Gene expression Health aspects Health sciences HIV HIV Core Protein p24 - metabolism HIV infection HIV Infections - prevention & control HIV-1 - metabolism Host factor Human immunodeficiency virus Human immunodeficiency virus 1 Humans Immunodeficiència Infections Karyopherins - antagonists & inhibitors Karyopherins - metabolism Metabolites Myxobacteria Myxococcales - metabolism Nuclear export Protein Binding Proteins Pyrones - chemistry Pyrones - metabolism Pyrones - pharmacology Ratjadone Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors Receptors, Cytoplasmic and Nuclear - metabolism Rev rev Gene Products, Human Immunodeficiency Virus - antagonists & inhibitors rev Gene Products, Human Immunodeficiency Virus - metabolism RNA missatger RNA, Messenger - metabolism VIH (Virus)
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