Mammalian Cdh1/Fzr mediates its own degradation

The A naphase‐ P romoting C omplex/ C yclosome (APC/C) ubiquitin ligase mediates degradation of cell cycle proteins during mitosis and G1. Cdc20/Fzy and Cdh1/Fzr are substrate‐specific APC/C activators. The level of mammalian Cdh1 is high in mitosis, but it is inactive and does not bind the APC/C. W...

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Veröffentlicht in:	The EMBO journal 2004-04, Vol.23 (7), p.1619-1626
Hauptverfasser:	Listovsky, Tamar, Oren, Yifat S, Yudkovsky, Yana, Mahbubani, Hiro M, Weiss, Aryeh M, Lebendiker, Mario, Brandeis, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Anaphase-Promoting Complex-Cyclosome Animals Antineoplastic Agents - metabolism APC/C cyclosome Degradation destruction box EMBO06 EMBO31 fizzy fizzy- related Freshwater Fzr protein G1 Phase - physiology Humans Mammalia Mammals Mice NIH 3T3 Cells Nocodazole - metabolism Oocytes - physiology Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Resting Phase, Cell Cycle - physiology Ubiquitin-Protein Ligase Complexes - genetics Ubiquitin-Protein Ligase Complexes - metabolism Xenopus Xenopus laevis
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