Somatic Mutation, Genomic Variation, and Neurological Disease

Genetic mutations causing human disease are conventionally thought to be inherited through the germ line from one's parents and present in all somatic (body) cells, except for most cancer mutations, which arise somatically. Increasingly, somatic mutations are being identified in diseases other...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2013-07, Vol.341 (6141), p.43-43
Hauptverfasser:	Poduri, Annapurna, Evrony, Gilad D., Cai, Xuyu, Walsh, Christopher A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Autism Autism Spectrum Disorders Brain Brain Diseases - genetics Brain Diseases - pathology Cancer Cellular Cerebral Cortex - growth & development Cerebral Cortex - metabolism Cerebral Cortex - pathology children Classical Lissencephalies and Subcortical Band Heterotopias - genetics Classical Lissencephalies and Subcortical Band Heterotopias - pathology Developmental Stages Disorders DNA Mutational Analysis Epilepsy Genetic mutation genetic variation Genetics genome Genomes genomics germ cells High-Throughput Nucleotide Sequencing Humans Intellectual Disability Lissencephaly - genetics Lissencephaly - pathology Mosaic Mosaicism Mutation Mutations Nervous system diseases Neurodegenerative diseases Neuroglia Neurological diseases Neurons Organisms Parents Progenitor cells REVIEW SUMMARY Somatic mutation
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