Social function in multiple X and Y chromosome disorders: XXY, XYY, XXYY, XXXY
Klinefelter syndrome (47,XXY) was initially described in the context of its endocrinologic and physical features; however, subsequent studies have revealed specific impairments in verbal skills and social functioning. Males with sex chromosomal aneuploidies are known to have variability in their dev...
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| Veröffentlicht in: | Developmental disabilities research reviews 2009, Vol.15 (4), p.328-332 |
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| description | Klinefelter syndrome (47,XXY) was initially described in the context of its endocrinologic and physical features; however, subsequent studies have revealed specific impairments in verbal skills and social functioning. Males with sex chromosomal aneuploidies are known to have variability in their developmental profile with the majority presenting with expressive language deficits. As a consequence of language delays, they have an increased likelihood of language‐based learning disabilities and social‐emotional problems that may persist through adulthood. Studies on males with 47,XXY have revealed unique behavioral and social profiles with possible vulnerability to autistic traits. The prevalence of males with more than one extra sex chromosome (e.g., 48,XXYY and 48,XXXY) and an additional Y (e.g., 47,XYY) is less common, but it is important to understand their social functioning as it provides insight into treatment implications. © 2009 Wiley‐Liss, Inc. Dev Disabil Res Rev 2009;15:328–332. |
| doi_str_mv | 10.1002/ddrr.76 |
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Males with sex chromosomal aneuploidies are known to have variability in their developmental profile with the majority presenting with expressive language deficits. As a consequence of language delays, they have an increased likelihood of language‐based learning disabilities and social‐emotional problems that may persist through adulthood. Studies on males with 47,XXY have revealed unique behavioral and social profiles with possible vulnerability to autistic traits. The prevalence of males with more than one extra sex chromosome (e.g., 48,XXYY and 48,XXXY) and an additional Y (e.g., 47,XYY) is less common, but it is important to understand their social functioning as it provides insight into treatment implications. © 2009 Wiley‐Liss, Inc. Dev Disabil Res Rev 2009;15:328–332.</description><identifier>ISSN: 1940-5510</identifier><identifier>EISSN: 1940-5529</identifier><identifier>DOI: 10.1002/ddrr.76</identifier><identifier>PMID: 20014367</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., a Wiley company</publisher><subject>47,XXY ; 47,XYY ; 48,XXXY ; 48,XXYY ; Aneuploidy ; Autism ; Autistic Disorder - epidemiology ; Autistic Disorder - genetics ; Chromosome Disorders - epidemiology ; Chromosome Disorders - genetics ; Chromosome Disorders - psychology ; Chromosomes, Human, X - genetics ; Chromosomes, Human, Y - genetics ; Emotional Problems ; Expressive Language ; Genetic Disorders ; Genetic Predisposition to Disease ; Genetics ; Humans ; Interpersonal Competence ; Klinefelter syndrome ; Klinefelter Syndrome - epidemiology ; Klinefelter Syndrome - genetics ; Klinefelter Syndrome - psychology ; Language Development Disorders - epidemiology ; Language Development Disorders - genetics ; Learning Disabilities ; Male ; Males ; Sex ; sex chromosomal aneuploidies ; Social Behavior ; Surveys and Questionnaires ; XXXY ; XXY ; XXYY ; XYY</subject><ispartof>Developmental disabilities research reviews, 2009, Vol.15 (4), p.328-332</ispartof><rights>Copyright © 2009 Wiley‐Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4946-a1da9552dbe96ab26bb57cacd0279522635463dd4e55d8c8d7fc4bc45287c2ee3</citedby><cites>FETCH-LOGICAL-c4946-a1da9552dbe96ab26bb57cacd0279522635463dd4e55d8c8d7fc4bc45287c2ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fddrr.76$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fddrr.76$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,4009,27902,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://eric.ed.gov/ERICWebPortal/detail?accno=EJ869383$$DView record in ERIC$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20014367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Visootsak, Jeannie</creatorcontrib><creatorcontrib>Graham Jr, John M.</creatorcontrib><title>Social function in multiple X and Y chromosome disorders: XXY, XYY, XXYY, XXXY</title><title>Developmental disabilities research reviews</title><addtitle>Dev Disabil Res Revs</addtitle><description>Klinefelter syndrome (47,XXY) was initially described in the context of its endocrinologic and physical features; however, subsequent studies have revealed specific impairments in verbal skills and social functioning. Males with sex chromosomal aneuploidies are known to have variability in their developmental profile with the majority presenting with expressive language deficits. As a consequence of language delays, they have an increased likelihood of language‐based learning disabilities and social‐emotional problems that may persist through adulthood. Studies on males with 47,XXY have revealed unique behavioral and social profiles with possible vulnerability to autistic traits. The prevalence of males with more than one extra sex chromosome (e.g., 48,XXYY and 48,XXXY) and an additional Y (e.g., 47,XYY) is less common, but it is important to understand their social functioning as it provides insight into treatment implications. © 2009 Wiley‐Liss, Inc. Dev Disabil Res Rev 2009;15:328–332.</description><subject>47,XXY</subject><subject>47,XYY</subject><subject>48,XXXY</subject><subject>48,XXYY</subject><subject>Aneuploidy</subject><subject>Autism</subject><subject>Autistic Disorder - epidemiology</subject><subject>Autistic Disorder - genetics</subject><subject>Chromosome Disorders - epidemiology</subject><subject>Chromosome Disorders - genetics</subject><subject>Chromosome Disorders - psychology</subject><subject>Chromosomes, Human, X - genetics</subject><subject>Chromosomes, Human, Y - genetics</subject><subject>Emotional Problems</subject><subject>Expressive Language</subject><subject>Genetic Disorders</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics</subject><subject>Humans</subject><subject>Interpersonal Competence</subject><subject>Klinefelter syndrome</subject><subject>Klinefelter Syndrome - epidemiology</subject><subject>Klinefelter Syndrome - genetics</subject><subject>Klinefelter Syndrome - psychology</subject><subject>Language Development Disorders - epidemiology</subject><subject>Language Development Disorders - genetics</subject><subject>Learning Disabilities</subject><subject>Male</subject><subject>Males</subject><subject>Sex</subject><subject>sex chromosomal aneuploidies</subject><subject>Social Behavior</subject><subject>Surveys and Questionnaires</subject><subject>XXXY</subject><subject>XXY</subject><subject>XXYY</subject><subject>XYY</subject><issn>1940-5510</issn><issn>1940-5529</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv1DAcxC0EoqVFfAGEfKIHSPHbMQekqo8tqCpSeWVPlmN7qUsSL3ZC229Pll2iciiXvy3NTzMjDQDPMNrHCJE3zqW0L8UDsI0VQwXnRD2c_hhtgSc5XyEksFD0MdgiCGFGhdwG55-iDaaBi6GzfYgdDB1sh6YPy8bDCprOwTm0lym2McfWQxdyTM6n_BZW1fw1rOars7nVfBc8Wpgm-6ebdwd8OTn-fHhanH2cvT88OCssU0wUBjujxpKu9kqYmoi65tIa6xCRihMiKGeCOsc85660pZMLy2rLOCmlJd7THfBu7bsc6tY767s-mUYvU2hNutXRBP2v0oVL_T3-0lQhxbEaDfY2Bin-HHzudRuy9U1jOh-HrCWlsmRKoJF8-V-SYKKYRHcsbYo5J7-Y6mCkVyvp1UpaipF8cbf9xP2dZQSerwGfgp3k4w_lOF9JR_nVWr4Ojb-9L0YfHV1c_Ekr1nTIvb-ZaJN-6DFKcv3tfKbJyaz8SsWpntHfZuKzMA</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>Visootsak, Jeannie</creator><creator>Graham Jr, John M.</creator><general>Wiley Subscription Services, Inc., a Wiley company</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>7SW</scope><scope>BJH</scope><scope>BNH</scope><scope>BNI</scope><scope>BNJ</scope><scope>BNO</scope><scope>ERI</scope><scope>PET</scope><scope>REK</scope><scope>WWN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2009</creationdate><title>Social function in multiple X and Y chromosome disorders: XXY, XYY, XXYY, XXXY</title><author>Visootsak, Jeannie ; Graham Jr, John M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4946-a1da9552dbe96ab26bb57cacd0279522635463dd4e55d8c8d7fc4bc45287c2ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>47,XXY</topic><topic>47,XYY</topic><topic>48,XXXY</topic><topic>48,XXYY</topic><topic>Aneuploidy</topic><topic>Autism</topic><topic>Autistic Disorder - epidemiology</topic><topic>Autistic Disorder - genetics</topic><topic>Chromosome Disorders - epidemiology</topic><topic>Chromosome Disorders - genetics</topic><topic>Chromosome Disorders - psychology</topic><topic>Chromosomes, Human, X - genetics</topic><topic>Chromosomes, Human, Y - genetics</topic><topic>Emotional Problems</topic><topic>Expressive Language</topic><topic>Genetic Disorders</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetics</topic><topic>Humans</topic><topic>Interpersonal Competence</topic><topic>Klinefelter syndrome</topic><topic>Klinefelter Syndrome - epidemiology</topic><topic>Klinefelter Syndrome - genetics</topic><topic>Klinefelter Syndrome - psychology</topic><topic>Language Development Disorders - epidemiology</topic><topic>Language Development Disorders - genetics</topic><topic>Learning Disabilities</topic><topic>Male</topic><topic>Males</topic><topic>Sex</topic><topic>sex chromosomal aneuploidies</topic><topic>Social Behavior</topic><topic>Surveys and Questionnaires</topic><topic>XXXY</topic><topic>XXY</topic><topic>XXYY</topic><topic>XYY</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Visootsak, Jeannie</creatorcontrib><creatorcontrib>Graham Jr, John M.</creatorcontrib><collection>Istex</collection><collection>ERIC</collection><collection>ERIC (Ovid)</collection><collection>ERIC</collection><collection>ERIC</collection><collection>ERIC (Legacy Platform)</collection><collection>ERIC( SilverPlatter )</collection><collection>ERIC</collection><collection>ERIC PlusText (Legacy Platform)</collection><collection>Education Resources Information Center (ERIC)</collection><collection>ERIC</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Developmental disabilities research reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Visootsak, Jeannie</au><au>Graham Jr, John M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><ericid>EJ869383</ericid><atitle>Social function in multiple X and Y chromosome disorders: XXY, XYY, XXYY, XXXY</atitle><jtitle>Developmental disabilities research reviews</jtitle><addtitle>Dev Disabil Res Revs</addtitle><date>2009</date><risdate>2009</risdate><volume>15</volume><issue>4</issue><spage>328</spage><epage>332</epage><pages>328-332</pages><issn>1940-5510</issn><eissn>1940-5529</eissn><abstract>Klinefelter syndrome (47,XXY) was initially described in the context of its endocrinologic and physical features; 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Males with sex chromosomal aneuploidies are known to have variability in their developmental profile with the majority presenting with expressive language deficits. As a consequence of language delays, they have an increased likelihood of language‐based learning disabilities and social‐emotional problems that may persist through adulthood. Studies on males with 47,XXY have revealed unique behavioral and social profiles with possible vulnerability to autistic traits. The prevalence of males with more than one extra sex chromosome (e.g., 48,XXYY and 48,XXXY) and an additional Y (e.g., 47,XYY) is less common, but it is important to understand their social functioning as it provides insight into treatment implications. © 2009 Wiley‐Liss, Inc. Dev Disabil Res Rev 2009;15:328–332.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., a Wiley company</pub><pmid>20014367</pmid><doi>10.1002/ddrr.76</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 47,XXY 47,XYY 48,XXXY 48,XXYY Aneuploidy Autism Autistic Disorder - epidemiology Autistic Disorder - genetics Chromosome Disorders - epidemiology Chromosome Disorders - genetics Chromosome Disorders - psychology Chromosomes, Human, X - genetics Chromosomes, Human, Y - genetics Emotional Problems Expressive Language Genetic Disorders Genetic Predisposition to Disease Genetics Humans Interpersonal Competence Klinefelter syndrome Klinefelter Syndrome - epidemiology Klinefelter Syndrome - genetics Klinefelter Syndrome - psychology Language Development Disorders - epidemiology Language Development Disorders - genetics Learning Disabilities Male Males Sex sex chromosomal aneuploidies Social Behavior Surveys and Questionnaires XXXY XXY XXYY XYY |
| title | Social function in multiple X and Y chromosome disorders: XXY, XYY, XXYY, XXXY |
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