Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids

Protein kinase C iota (PKCι), a serine/threonine kinase required for cell polarity, proliferation and migration, is commonly up- or downregulated in cancer. PKCι is a human oncogene but whether this is related to its role in cell polarity and what repertoire of oncogenes acts in concert with PKCι is...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Carcinogenesis (New York) 2014-02, Vol.35 (2), p.396-406
Hauptverfasser:	Linch, Mark, Sanz-Garcia, Marta, Rosse, Carine, Riou, Philippe, Peel, Nick, Madsen, Chris D, Sahai, Erik, Downward, Julian, Khwaja, Asim, Dillon, Christian, Roffey, Jon, Cameron, Angus J M, Parker, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Polarity Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Cells, Cultured Cysts - metabolism Cysts - pathology Dogs Epithelial Cells - metabolism Epithelial Cells - pathology Genes, ras - physiology Humans Isoenzymes - antagonists & inhibitors Isoenzymes - genetics Isoenzymes - metabolism Kidney - metabolism Kidney - pathology Morphogenesis - physiology Original Manuscript Phosphatidylinositol 3-Kinase - metabolism Protein Kinase C - antagonists & inhibitors Protein Kinase C - genetics Protein Kinase C - metabolism Receptor, ErbB-2 - metabolism RNA, Small Interfering - genetics Spheroids, Cellular - metabolism Spheroids, Cellular - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!