Neuroprotective strategies for traumatic brain injury: improving clinical translation
Traumatic brain injury (TBI) induces secondary biochemical changes that contribute to delayed neuroinflammation, neuronal cell death, and neurological dysfunction. Attenuating such secondary injury has provided the conceptual basis for neuroprotective treatments. Despite strong experimental data, mo...
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| Veröffentlicht in: | International journal of molecular sciences 2014-01, Vol.15 (1), p.1216-1236 |
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| container_title | International journal of molecular sciences |
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| creator | Kabadi, Shruti V Faden, Alan I |
| description | Traumatic brain injury (TBI) induces secondary biochemical changes that contribute to delayed neuroinflammation, neuronal cell death, and neurological dysfunction. Attenuating such secondary injury has provided the conceptual basis for neuroprotective treatments. Despite strong experimental data, more than 30 clinical trials of neuroprotection in TBI patients have failed. In part, these failures likely reflect methodological differences between the clinical and animal studies, as well as inadequate pre-clinical evaluation and/or trial design problems. However, recent changes in experimental approach and advances in clinical trial methodology have raised the potential for successful clinical translation. Here we critically analyze the current limitations and translational opportunities for developing successful neuroprotective therapies for TBI. |
| doi_str_mv | 10.3390/ijms15011216 |
| format | Article |
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Here we critically analyze the current limitations and translational opportunities for developing successful neuroprotective therapies for TBI.</description><subject>Animals</subject><subject>Brain Injuries - drug therapy</subject><subject>Clinical Trials as Topic</subject><subject>Humans</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>Review</subject><subject>Translational Medical Research - methods</subject><subject>Translational Medical Research - standards</subject><issn>1422-0067</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTtPwzAUhS0EolDYmFFGBgrXjzgxAxKqeEkVLHS2HNcprhK72Eml_ntctaAyMV1f-fPROT4IXWC4oVTArV20EeeAMcH8AJ1gRsgIgBeHe-cBOo1xAUAoycUxGhDGWE7y8gRN30wf_DL4zujOrkwWu6A6M7cmZrUPWdr6VnVWZ1VQ1mXWLfqwvstsm96srJtnurHOatVsUBebxHp3ho5q1URzvptDNH16_Bi_jCbvz6_jh8lIs5J2o9LUVPCKMy5MSau6UBSYriCHohAzPNOFqjQhRAAIKkSd12LGa23KAqDUwOkQ3W91l33Vmpk2Lplo5DLYVoW19MrKvzfOfsq5X8n0cUXJ8yRwtRMI_qs3sZOtjdo0jXLG91HiIqeMJz_4f5QJwkvgKdkQXW9RHXyMwdS_jjDITWlyv7SEX-6n-IV_WqLfsQ6VFA</recordid><startdate>20140117</startdate><enddate>20140117</enddate><creator>Kabadi, Shruti V</creator><creator>Faden, Alan I</creator><general>Molecular Diversity Preservation International (MDPI)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20140117</creationdate><title>Neuroprotective strategies for traumatic brain injury: improving clinical translation</title><author>Kabadi, Shruti V ; Faden, Alan I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-8ef396b6469e83bf7a304cb050779d1dc7abc2229009399f5f9d6fce87008c063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Brain Injuries - drug therapy</topic><topic>Clinical Trials as Topic</topic><topic>Humans</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>Review</topic><topic>Translational Medical Research - methods</topic><topic>Translational Medical Research - standards</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kabadi, Shruti V</creatorcontrib><creatorcontrib>Faden, Alan I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kabadi, Shruti V</au><au>Faden, Alan I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroprotective strategies for traumatic brain injury: improving clinical translation</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2014-01-17</date><risdate>2014</risdate><volume>15</volume><issue>1</issue><spage>1216</spage><epage>1236</epage><pages>1216-1236</pages><issn>1422-0067</issn><eissn>1422-0067</eissn><abstract>Traumatic brain injury (TBI) induces secondary biochemical changes that contribute to delayed neuroinflammation, neuronal cell death, and neurological dysfunction. 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| source | MEDLINE; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Brain Injuries - drug therapy Clinical Trials as Topic Humans Neuroprotective Agents - therapeutic use Review Translational Medical Research - methods Translational Medical Research - standards |
| title | Neuroprotective strategies for traumatic brain injury: improving clinical translation |
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