A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly

The Schizosaccharomyces pombe HP1 protein, Swi6, is shown to exist in an auto-inhibited state when unbound to chromatin, switching to a spreading-competent state upon binding to the HK9 methyl mark; disrupting this switch affects heterochromatin assembly and gene silencing. On–off switch for heteroc...

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Veröffentlicht in:	Nature (London) 2013-04, Vol.496 (7445), p.377-381
Hauptverfasser:	Canzio, Daniele, Liao, Maofu, Naber, Nariman, Pate, Edward, Larson, Adam, Wu, Shenping, Marina, Diana B., Garcia, Jennifer F., Madhani, Hiten D., Cooke, Roger, Schuck, Peter, Cheng, Yifan, Narlikar, Geeta J.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/100 631/45/147 Amino Acid Sequence Animals Binding sites Chromatin Chromatin Assembly and Disassembly Chromosomal Proteins, Non-Histone - antagonists & inhibitors Chromosomal Proteins, Non-Histone - chemistry Chromosomal Proteins, Non-Histone - metabolism Chromosomal Proteins, Non-Histone - ultrastructure Cryoelectron Microscopy Gene Silencing Heterochromatin - chemistry Heterochromatin - metabolism Heterochromatin - ultrastructure Histones - chemistry Histones - metabolism Humanities and Social Sciences Kinases letter Methylation Models, Molecular Molecular Sequence Data multidisciplinary Nucleosomes - chemistry Nucleosomes - genetics Nucleosomes - metabolism Nucleosomes - ultrastructure Peptides Protein Structure, Tertiary Proteins Schizosaccharomyces - genetics Schizosaccharomyces - metabolism Schizosaccharomyces pombe Proteins - antagonists & inhibitors Schizosaccharomyces pombe Proteins - chemistry Schizosaccharomyces pombe Proteins - metabolism Schizosaccharomyces pombe Proteins - ultrastructure Science Xenopus laevis Yeasts
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