Delays Induce Novel Stochastic Effects in Negative Feedback Gene Circuits

Stochastic models of reaction networks are widely used to depict gene expression dynamics. However, stochastic does not necessarily imply accurate, as subtle assumptions can yield erroneous results, masking key discrete effects. For instance, transcription and translation are not instantaneous proce...

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Veröffentlicht in:	Biophysical journal 2014-01, Vol.106 (2), p.467-478
Hauptverfasser:	Zavala, Eder, Marquez-Lago, Tatiana T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Feedback Feedback, Physiological Gene expression Gene Regulatory Networks Genes Genetics Models, Genetic Stochastic models Stochastic Processes Systems Biology Systems Biophysics Time Factors Transcription, Genetic
Online-Zugang:	Volltext
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