Identification and Validation of an Anthracycline/ Cyclophosphamide-Based Chemotherapy Response Assay in Breast Cancer

There is no method routinely used to predict response to anthracycline and cyclophosphamide-based chemotherapy in the clinic; therefore patients often receive treatment for breast cancer with no benefit. Loss of the Fanconi anemia/BRCA (FA/BRCA) DNA damage response (DDR) pathway occurs in approximat...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2014-01, Vol.106 (1), p.djt335
Hauptverfasser:	MULLIGAN, Jude M, HILL, Laura A, QUINN, Jennifer E, LINDOR, Noralane M, MULLAN, Paul B, JAMES, Colin R, WALKER, Steven M, KERR, Peter, JAMES, Jacqueline, DAVISON, Timothy S, PROUTSKI, Vitali, SALTO-TELLEZ, Manuel, DEHARO, Steve, JOHNSTON, Patrick G, COUCH, Fergus J, HARKIN, D. Paul, KENNEDY, Richard D, IRWIN, Gareth, BOYLE, David, KEATING, Katherine E, RAJI, Olaide Y, MCDYER, Fionnuala A, O'BRIEN, Eamonn, BYLESJO, Max
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anthracyclines - administration & dosage Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bioassays Biological and medical sciences Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Chemotherapy Chemotherapy, Adjuvant Cyclophosphamide - administration & dosage Disease-Free Survival DNA damage DNA Damage - drug effects DNA, Neoplasm - drug effects Epirubicin - administration & dosage Fanconi Anemia - genetics Fanconi Anemia - metabolism Female Fluorouracil - administration & dosage Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical prognosis Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoadjuvant Therapy - methods Odds Ratio Oligonucleotide Array Sequence Analysis Prospective Studies Survival analysis Tumors
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