PNU-91325 increases fatty acid synthesis from glucose and mitochondrial long chain fatty acid degradation: a comparative tracer-based metabolomics study with rosiglitazone and pioglitazone in HepG2 cells

The mitochondrial membrane protein termed "mitoNEET," is a putative secondary target for insulin-sensitizing thiazolidinedione (TZD) compounds but its role in regulating metabolic flux is not known. PNU-91325 is a thiazolidinedione derivative which exhibits high binding affinity to mitoNEE...

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Veröffentlicht in:	Metabolomics 2006-03, Vol.2 (1), p.21-29
Hauptverfasser:	Harrigan, George G, Colca, Jerry, Szalma, Sándor, Boros, László G
Format:	Artikel
Sprache:	eng
Schlagworte:	Fatty acids Metabolites
Online-Zugang:	Volltext
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