A Novel Vascular Homing Peptide Strategy to Selectively Enhance Pulmonary Drug Efficacy in Pulmonary Arterial Hypertension

A major limitation in the pharmacological treatment of pulmonary arterial hypertension (PAH) is the lack of pulmonary vascular selectivity. Recent studies have identified a tissue-penetrating homing peptide, CARSKNKDC (CAR), which specifically homes to hypertensive pulmonary arteries but not to norm...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The American journal of pathology 2014-02, Vol.184 (2), p.369-375
Hauptverfasser:	Toba, Michie, Alzoubi, Abdallah, O’Neill, Kealan, Abe, Kohtaro, Urakami, Takeo, Komatsu, Masanobu, Alvarez, Diego, Järvinen, Tero A.H, Mann, David, Ruoslahti, Erkki, McMurtry, Ivan F, Oka, Masahiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Sublingual Amino Acid Sequence Animals Arterial Occlusive Diseases - drug therapy Arterial Occlusive Diseases - pathology Benzamides - pharmacology Benzamides - therapeutic use Drug Delivery Systems - methods Familial Primary Pulmonary Hypertension Hemodynamics - drug effects Hypertension, Pulmonary - drug therapy Hypertension, Pulmonary - pathology Hypertension, Pulmonary - physiopathology Imatinib Mesylate Infusions, Intravenous Injections, Intravenous Male Molecular Sequence Data Pathology Peptides - chemistry Piperazines - pharmacology Piperazines - therapeutic use Pulmonary Artery - drug effects Pulmonary Artery - pathology Pulmonary Artery - physiopathology Pyrimidines - pharmacology Pyrimidines - therapeutic use Rats Rats, Sprague-Dawley Short Communication Treatment Outcome Vasodilator Agents - administration & dosage Vasodilator Agents - pharmacology Vasodilator Agents - therapeutic use
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!