New relationships of human hematopoietic lineages facilitate detection of multipotent hematopoietic stem and progenitor cells
Three important goals of hematopoietic stem cell research are to understand of how hematopoietic stem cells (HSCs) self-renew, how lineage commitment takes place, and how HSCs can be expanded ex vivo. Research in this area requires a reliable model of hematopoiesis. Performing detailed functional an...
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| Veröffentlicht in: | Cell cycle (Georgetown, Tex.) Tex.), 2013-11, Vol.12 (22), p.3478-3482 |
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| container_title | Cell cycle (Georgetown, Tex.) |
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| creator | Görgens, Andre Radtke, Stefan Horn, Peter Giebel, Bernd |
| description | Three important goals of hematopoietic stem cell research are to understand of how hematopoietic stem cells (HSCs) self-renew, how lineage commitment takes place, and how HSCs can be expanded ex vivo. Research in this area requires a reliable model of hematopoiesis. Performing detailed functional analyses of human hematopoietic progenitor subsets, we recently gained evidence for new hematopoietic lineage relationships.
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According to our data, neutrophils belong to the same branch of the hematopoietic tree as lymphocytes. In contrast, eosinophils and basophils derive from another branch, the erythro-myeloid branch. Here, after introducing the newly proposed hematopoietic model, we discuss its consequences for the identification and expansion of human multipotent progenitors and suggest a fast and reliable method to screen for multipotent hematopoietic cells in vitro. |
| doi_str_mv | 10.4161/cc.26900 |
| format | Article |
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1
According to our data, neutrophils belong to the same branch of the hematopoietic tree as lymphocytes. In contrast, eosinophils and basophils derive from another branch, the erythro-myeloid branch. Here, after introducing the newly proposed hematopoietic model, we discuss its consequences for the identification and expansion of human multipotent progenitors and suggest a fast and reliable method to screen for multipotent hematopoietic cells in vitro.</description><identifier>ISSN: 1538-4101</identifier><identifier>EISSN: 1551-4005</identifier><identifier>DOI: 10.4161/cc.26900</identifier><identifier>PMID: 24189527</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Animals ; CD133 ; Cell Lineage ; EMPs ; Extra Views ; GMPs ; Hematopoiesis - physiology ; hematopoietic stem cells ; Hematopoietic Stem Cells - physiology ; human hematopoiesis ; Humans ; LMPPs ; MEPs ; MPPs ; Multipotent Stem Cells - physiology ; progenitors</subject><ispartof>Cell cycle (Georgetown, Tex.), 2013-11, Vol.12 (22), p.3478-3482</ispartof><rights>Copyright © 2013 Landes Bioscience 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-fa5ef1b5b7629eb41dbbcbc5feaf904f567dec2a5a528e42bda903a6d953f0cd3</citedby><cites>FETCH-LOGICAL-c482t-fa5ef1b5b7629eb41dbbcbc5feaf904f567dec2a5a528e42bda903a6d953f0cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906333/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906333/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24189527$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Görgens, Andre</creatorcontrib><creatorcontrib>Radtke, Stefan</creatorcontrib><creatorcontrib>Horn, Peter</creatorcontrib><creatorcontrib>Giebel, Bernd</creatorcontrib><title>New relationships of human hematopoietic lineages facilitate detection of multipotent hematopoietic stem and progenitor cells</title><title>Cell cycle (Georgetown, Tex.)</title><addtitle>Cell Cycle</addtitle><description>Three important goals of hematopoietic stem cell research are to understand of how hematopoietic stem cells (HSCs) self-renew, how lineage commitment takes place, and how HSCs can be expanded ex vivo. Research in this area requires a reliable model of hematopoiesis. Performing detailed functional analyses of human hematopoietic progenitor subsets, we recently gained evidence for new hematopoietic lineage relationships.
1
According to our data, neutrophils belong to the same branch of the hematopoietic tree as lymphocytes. In contrast, eosinophils and basophils derive from another branch, the erythro-myeloid branch. Here, after introducing the newly proposed hematopoietic model, we discuss its consequences for the identification and expansion of human multipotent progenitors and suggest a fast and reliable method to screen for multipotent hematopoietic cells in vitro.</description><subject>Animals</subject><subject>CD133</subject><subject>Cell Lineage</subject><subject>EMPs</subject><subject>Extra Views</subject><subject>GMPs</subject><subject>Hematopoiesis - physiology</subject><subject>hematopoietic stem cells</subject><subject>Hematopoietic Stem Cells - physiology</subject><subject>human hematopoiesis</subject><subject>Humans</subject><subject>LMPPs</subject><subject>MEPs</subject><subject>MPPs</subject><subject>Multipotent Stem Cells - physiology</subject><subject>progenitors</subject><issn>1538-4101</issn><issn>1551-4005</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkU9vFSEUxYnR2Po08RMYlm6mAgPzZjYmplFr0uhG1-QOXN7DMDACY9OF392ZttZ_bCC5v3PuIYeQ55ydSd7xV8aciW5g7AE55UrxRjKmHm7vtm8kZ_yEPCnlK2Oi3w_8MTkRkveDEvtT8uMjXtGMAapPsRz9XGhy9LhMEOkRJ6hpTh6rNzT4iHDAQh0YH3yFitRiRbMpN9G0hOrnVDHWf6Sl4kQhWjrndMDoa8rUYAjlKXnkIBR8dnfvyJd3bz-fXzSXn95_OH9z2RjZi9o4UOj4qMZ9JwYcJbfjaEajHIIbmHSq21s0AhQo0aMUo4WBtdDZQbWOGdvuyOtb33kZJ7RmjZgh6Dn7CfK1TuD135Poj_qQvut2YF27nh15eWeQ07cFS9WTL9sXIGJaiuZSDUr1K_4bNTmVktHdr-FMb21pY_RNWyv64s9Y9-CvelagvQV8dClPcJVysLrCdUjZZYjGF93-Z_sTgg2nfg</recordid><startdate>20131115</startdate><enddate>20131115</enddate><creator>Görgens, Andre</creator><creator>Radtke, Stefan</creator><creator>Horn, Peter</creator><creator>Giebel, Bernd</creator><general>Taylor & Francis</general><general>Landes Bioscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20131115</creationdate><title>New relationships of human hematopoietic lineages facilitate detection of multipotent hematopoietic stem and progenitor cells</title><author>Görgens, Andre ; Radtke, Stefan ; Horn, Peter ; Giebel, Bernd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-fa5ef1b5b7629eb41dbbcbc5feaf904f567dec2a5a528e42bda903a6d953f0cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>CD133</topic><topic>Cell Lineage</topic><topic>EMPs</topic><topic>Extra Views</topic><topic>GMPs</topic><topic>Hematopoiesis - physiology</topic><topic>hematopoietic stem cells</topic><topic>Hematopoietic Stem Cells - physiology</topic><topic>human hematopoiesis</topic><topic>Humans</topic><topic>LMPPs</topic><topic>MEPs</topic><topic>MPPs</topic><topic>Multipotent Stem Cells - physiology</topic><topic>progenitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Görgens, Andre</creatorcontrib><creatorcontrib>Radtke, Stefan</creatorcontrib><creatorcontrib>Horn, Peter</creatorcontrib><creatorcontrib>Giebel, Bernd</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell cycle (Georgetown, Tex.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Görgens, Andre</au><au>Radtke, Stefan</au><au>Horn, Peter</au><au>Giebel, Bernd</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New relationships of human hematopoietic lineages facilitate detection of multipotent hematopoietic stem and progenitor cells</atitle><jtitle>Cell cycle (Georgetown, Tex.)</jtitle><addtitle>Cell Cycle</addtitle><date>2013-11-15</date><risdate>2013</risdate><volume>12</volume><issue>22</issue><spage>3478</spage><epage>3482</epage><pages>3478-3482</pages><issn>1538-4101</issn><eissn>1551-4005</eissn><abstract>Three important goals of hematopoietic stem cell research are to understand of how hematopoietic stem cells (HSCs) self-renew, how lineage commitment takes place, and how HSCs can be expanded ex vivo. Research in this area requires a reliable model of hematopoiesis. Performing detailed functional analyses of human hematopoietic progenitor subsets, we recently gained evidence for new hematopoietic lineage relationships.
1
According to our data, neutrophils belong to the same branch of the hematopoietic tree as lymphocytes. In contrast, eosinophils and basophils derive from another branch, the erythro-myeloid branch. Here, after introducing the newly proposed hematopoietic model, we discuss its consequences for the identification and expansion of human multipotent progenitors and suggest a fast and reliable method to screen for multipotent hematopoietic cells in vitro.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>24189527</pmid><doi>10.4161/cc.26900</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cell cycle (Georgetown, Tex.), 2013-11, Vol.12 (22), p.3478-3482 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals CD133 Cell Lineage EMPs Extra Views GMPs Hematopoiesis - physiology hematopoietic stem cells Hematopoietic Stem Cells - physiology human hematopoiesis Humans LMPPs MEPs MPPs Multipotent Stem Cells - physiology progenitors |
| title | New relationships of human hematopoietic lineages facilitate detection of multipotent hematopoietic stem and progenitor cells |
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