ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage

The kinase ATR is activated by RPA-coated single-stranded DNA generated at aberrant replicative structures and resected double strand breaks. While many hundred candidate ATR substrates have been identified, the essential role of ATR in the replicative stress response has impeded the study of ATR ki...

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Veröffentlicht in:	Nucleic acids research 2013-12, Vol.41 (22), p.10334-10344
Hauptverfasser:	Gamper, Armin M, Rofougaran, Reza, Watkins, Simon C, Greenberger, Joel S, Beumer, Jan H, Bakkenist, Christopher J
Format:	Artikel
Sprache:	eng
Schlagworte:	Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors Ataxia Telangiectasia Mutated Proteins - metabolism Cell Line Checkpoint Kinase 1 DNA Damage DNA Repair G1 Phase - genetics G1 Phase - radiation effects Genome Integrity, Repair and Humans Protein Kinases - metabolism Radiation Tolerance Radiation, Ionizing Replication Protein A - analysis Signal Transduction
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