Stress-Regulated Translational Attenuation Adapts Mitochondrial Protein Import through Tim17A Degradation

Stress-regulated signaling pathways protect mitochondrial proteostasis and function from pathologic insults. Despite the importance of stress-regulated signaling pathways in mitochondrial proteome maintenance, the molecular mechanisms by which these pathways maintain mitochondrial proteostasis remai...

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Veröffentlicht in:	Cell metabolism 2013-12, Vol.18 (6), p.908-919
Hauptverfasser:	Rainbolt, T. Kelly, Atanassova, Neli, Genereux, Joseph C., Wiseman, R. Luke
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arsenic - toxicity ATPases Associated with Diverse Cellular Activities Caenorhabditis elegans - metabolism Cell Line Eukaryotic Initiation Factor-2 - metabolism HEK293 Cells HeLa Cells Humans Metalloendopeptidases - antagonists & inhibitors Metalloendopeptidases - genetics Metalloendopeptidases - metabolism Mice Mitochondria - drug effects Mitochondria - metabolism Mitochondrial Membrane Transport Proteins - antagonists & inhibitors Mitochondrial Membrane Transport Proteins - genetics Mitochondrial Membrane Transport Proteins - metabolism Mitochondrial Proteins Oxidative Stress - drug effects Paraquat - toxicity Phosphorylation Protein Biosynthesis - drug effects Protein Transport - drug effects Unfolded Protein Response - drug effects
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