Human Formalin-Fixed Paraffin-Embedded Tissues: An Untapped Specimen for Biomonitoring of Carcinogen DNA Adducts by Mass Spectrometry

DNA adducts represent internal dosimeters to measure exposure to environmental and endogenous genotoxicants. Unfortunately, in molecular epidemiologic studies, measurements of DNA adducts often are precluded by the unavailability of fresh tissue. In contrast, formalin-fixed paraffin embedded (FFPE)...

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Veröffentlicht in:	Analytical chemistry (Washington) 2013-05, Vol.85 (9), p.4251-4258
Hauptverfasser:	Yun, Byeong Hwa, Rosenquist, Thomas A, Nikolić, Jovan, Dragičević, Dejan, Tomić, Karla, Jelaković, Bojan, Dickman, Kathleen G, Grollman, Arthur P, Turesky, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Animals Aristolochic Acids - chemistry Biomarkers Carcinogens Carcinogens - analysis Chromatography Chromatography, Liquid Deoxyribonucleic acid DNA DNA Adducts - analysis Epidemiology Formaldehyde - chemistry Humans Kidney Neoplasms - pathology Male Mass Spectrometry Mice Mice, Inbred C57BL Molecular Structure Paraffin Embedding Tissue Fixation Ureteral Neoplasms - pathology
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