Association between ABCB1-T1236C polymorphism and drug-resistant epilepsy in Iranian female patients

One third of epileptic patients are resistant to several anti-epileptic drugs (AED). P-glycoprotein (P-gp) is an efflux transporter encoded by ATP-binding cassette subfamily B member 1 (ABCB1) gene that excludes drugs from the cells and plays a significant role in AEDs resistance. Over-expression of...

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Veröffentlicht in:	Iranian biomedical journal 2010-07, Vol.14 (3), p.89-96
Hauptverfasser:	Maleki, Mehri, Sayyah, Mohammad, Kamgarpour, Fatemeh, Karimipoor, Morteza, Arab, Aida, Rajabi, Anahita, Gharagozli, Kourosh, Shamshiri, Ahmad Reza, Shahsavand Ananloo, Esmaeil
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acid Substitution - genetics ATP Binding Cassette Transporter, Sub-Family B ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Case-Control Studies Demography Drug Resistance - genetics Epilepsy - genetics Female Gene Frequency - genetics Genetic Association Studies Genetic Predisposition to Disease Humans Iran Male Odds Ratio Original Polymorphism, Single Nucleotide - genetics
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