Resveratrol and EGCG bind directly and distinctively to miR-33a and miR-122 and modulate divergently their levels in hepatic cells

Modulation of miR-33 and miR-122 has been proposed to be a promising strategy to treat dyslipidemia and insulin resistance associated with obesity and metabolic syndrome. Interestingly, specific polyphenols reduce the levels of these mi(cro)RNAs. The aim of this study was to elucidate the effect of...

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Veröffentlicht in:	Nucleic acids research 2014-01, Vol.42 (2), p.882-892
Hauptverfasser:	Baselga-Escudero, Laura, Blade, Cinta, Ribas-Latre, Aleix, Casanova, Ester, Suárez, Manuel, Torres, Josep Lluís, Salvadó, M Josepa, Arola, Lluis, Arola-Arnal, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Binding Cassette Transporter 1 - metabolism Catechin - analogs & derivatives Catechin - chemistry Catechin - pharmacology Cell Line, Tumor Fatty Acid Synthases - metabolism Flavonoids - chemistry Flavonoids - pharmacology Gene Regulation, Chromatin and Epigenetics Humans Liver - cytology Liver - metabolism MicroRNAs - drug effects MicroRNAs - metabolism Plant Extracts - chemistry Polyphenols - chemistry Polyphenols - pharmacology Rats Resveratrol Sterol Regulatory Element Binding Protein 2 - genetics Stilbenes - chemistry Stilbenes - pharmacology Vitis - chemistry
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