Amitriptyline, clomipramine, and doxepin adsorption onto sodium polystyrene sulfonate
Purpose of the study Comparative in vitro studies were carried out to determine the adsorption characteristics of 3 drugs on activated charcoal (AC) and sodium polystyrene sulfonate (SPS). Activated charcoal (AC) has been long used as gastric decontamination agent for tricyclic antidepressants (TCA)...
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| Veröffentlicht in: | Daru 2014-01, Vol.22 (1), p.21-21, Article 21 |
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| creator | Jamshidzadeh, Akram Vahedi, Fatemeh Farshad, Omid Seradj, Hassan Najibi, Asma Dehghanzadeh, Gholamreza |
| description | Purpose of the study
Comparative in vitro studies were carried out to determine the adsorption characteristics of 3 drugs on activated charcoal (AC) and sodium polystyrene sulfonate (SPS). Activated charcoal (AC) has been long used as gastric decontamination agent for tricyclic antidepressants (TCA).
Methods
Solutions containing drugs (amitriptyline, clomipramine, or doxepin) and variable amount of AC or SPS were incubated for 30 minutes.
Results
At pH 1.2 the adsorbent: drug mass ratio varied from 2 : 1 to 40 : 1 for AC, and from 0.4 : 1 to 8 : 1 for SPS. UV–VIS spectrophotometer was used for the determination of free drug concentrations. The qmax of amitriptyline was 0.055 mg/mg AC and 0.574 mg/mg SPS, qmax of clomipramine was 0.053 mg/mg AC and 0.572 mg/mg SPS, and qmax of doxepin was 0.045 mg/mg AC and 0.556 mg/mg SPS. The results of adsorption experiments with SPS revealed higher values for the qmax parameters in comparison with AC.
Conclusion
In vitro gastric decontamination experiments for antidepressant amitriptyline, clomipramine, and doxepin showed that SPS has higher qmax values than the corresponding experiments with AC. Therefore, we suggest SPS is a better gastric decontaminating agent for the management of acute TCA intoxication. |
| doi_str_mv | 10.1186/2008-2231-22-21 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3902433</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A541258967</galeid><sourcerecordid>A541258967</sourcerecordid><originalsourceid>FETCH-LOGICAL-c659t-953ebe11a4e9eecaa816f9d1b4ea49d9a65925a3aedc88aed4ad546bbb67358c3</originalsourceid><addsrcrecordid>eNqFkk2LFDEQhoMo7jp69iYNgniwd_O9yUUYFr9gwYt7Dunu6pks6aRNusX596addZwRRQIVUnnqJVV5EXpO8AUhSl5SjFVNKSMl1JQ8QOeHzEN0ToTEtSJEnKEnOd9hzBSX9DE6o5wLzDQ5R7frwU3JjdPOuwBvqtbHwY3JDj9PNnRVF7_D6EJluxzTOLkYqhimWOXYuXmoxuh3edolCFDl2fcx2Ameoke99Rme3e8rdPv-3Zfrj_XN5w-frtc3dSuFnmotGDRAiOWgAVprFZG97kjDwXLdaVsoKiyz0LVKlchtJ7hsmkZeMaFatkJv97rj3AwFgjAl682Y3GDTzkTrzOlNcFuzid8M05hyxorA63uBFL_OkCczuNyC9zZAnLMhglDGqJTy_yjX9IpoKUlBX_6B3sU5hTKJIogZ1lxJ_JvaWA_GhT6WJ7aLqFkLTqhQurS5Qhd_ocrqYHBtDNC7kj8peHVUsAXrp22Ofl5-Lp-Cl3uwTTHnBP1hbgSbxV1m8ZJZvFSCoUtfL47HfeB_2akAeA_kchU2kI4a_4fmDw9g2RQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1503094860</pqid></control><display><type>article</type><title>Amitriptyline, clomipramine, and doxepin adsorption onto sodium polystyrene sulfonate</title><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><source>SpringerLink Journals - AutoHoldings</source><creator>Jamshidzadeh, Akram ; Vahedi, Fatemeh ; Farshad, Omid ; Seradj, Hassan ; Najibi, Asma ; Dehghanzadeh, Gholamreza</creator><creatorcontrib>Jamshidzadeh, Akram ; Vahedi, Fatemeh ; Farshad, Omid ; Seradj, Hassan ; Najibi, Asma ; Dehghanzadeh, Gholamreza</creatorcontrib><description>Purpose of the study
Comparative in vitro studies were carried out to determine the adsorption characteristics of 3 drugs on activated charcoal (AC) and sodium polystyrene sulfonate (SPS). Activated charcoal (AC) has been long used as gastric decontamination agent for tricyclic antidepressants (TCA).
Methods
Solutions containing drugs (amitriptyline, clomipramine, or doxepin) and variable amount of AC or SPS were incubated for 30 minutes.
Results
At pH 1.2 the adsorbent: drug mass ratio varied from 2 : 1 to 40 : 1 for AC, and from 0.4 : 1 to 8 : 1 for SPS. UV–VIS spectrophotometer was used for the determination of free drug concentrations. The qmax of amitriptyline was 0.055 mg/mg AC and 0.574 mg/mg SPS, qmax of clomipramine was 0.053 mg/mg AC and 0.572 mg/mg SPS, and qmax of doxepin was 0.045 mg/mg AC and 0.556 mg/mg SPS. The results of adsorption experiments with SPS revealed higher values for the qmax parameters in comparison with AC.
Conclusion
In vitro gastric decontamination experiments for antidepressant amitriptyline, clomipramine, and doxepin showed that SPS has higher qmax values than the corresponding experiments with AC. Therefore, we suggest SPS is a better gastric decontaminating agent for the management of acute TCA intoxication.</description><identifier>ISSN: 1560-8115</identifier><identifier>ISSN: 2008-2231</identifier><identifier>EISSN: 2008-2231</identifier><identifier>DOI: 10.1186/2008-2231-22-21</identifier><identifier>PMID: 24450391</identifier><language>eng</language><publisher>London: BioMed Central</publisher><subject>Adsorbents ; Adsorption ; Biomedical and Life Sciences ; Biomedicine ; Charcoal ; Drugs ; Equilibrium ; Experiments ; Medicinal Chemistry ; Pharmaceutical industry ; Pharmaceutical Sciences/Technology ; Pharmacology/Toxicology ; Poisoning ; Potassium ; Prescription drugs ; Research Article ; Sodium</subject><ispartof>Daru, 2014-01, Vol.22 (1), p.21-21, Article 21</ispartof><rights>Jamshidzadeh et al.; licensee BioMed Central Ltd. 2014</rights><rights>COPYRIGHT 2014 BioMed Central Ltd.</rights><rights>Copyright Tehran University of Medical Sciences Publications Jan 2014</rights><rights>Copyright © 2014 Jamshidzadeh et al.; licensee BioMed Central Ltd. 2014 Jamshidzadeh et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c659t-953ebe11a4e9eecaa816f9d1b4ea49d9a65925a3aedc88aed4ad546bbb67358c3</citedby><cites>FETCH-LOGICAL-c659t-953ebe11a4e9eecaa816f9d1b4ea49d9a65925a3aedc88aed4ad546bbb67358c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902433/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902433/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24450391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jamshidzadeh, Akram</creatorcontrib><creatorcontrib>Vahedi, Fatemeh</creatorcontrib><creatorcontrib>Farshad, Omid</creatorcontrib><creatorcontrib>Seradj, Hassan</creatorcontrib><creatorcontrib>Najibi, Asma</creatorcontrib><creatorcontrib>Dehghanzadeh, Gholamreza</creatorcontrib><title>Amitriptyline, clomipramine, and doxepin adsorption onto sodium polystyrene sulfonate</title><title>Daru</title><addtitle>DARU J Pharm Sci</addtitle><addtitle>Daru</addtitle><description>Purpose of the study
Comparative in vitro studies were carried out to determine the adsorption characteristics of 3 drugs on activated charcoal (AC) and sodium polystyrene sulfonate (SPS). Activated charcoal (AC) has been long used as gastric decontamination agent for tricyclic antidepressants (TCA).
Methods
Solutions containing drugs (amitriptyline, clomipramine, or doxepin) and variable amount of AC or SPS were incubated for 30 minutes.
Results
At pH 1.2 the adsorbent: drug mass ratio varied from 2 : 1 to 40 : 1 for AC, and from 0.4 : 1 to 8 : 1 for SPS. UV–VIS spectrophotometer was used for the determination of free drug concentrations. The qmax of amitriptyline was 0.055 mg/mg AC and 0.574 mg/mg SPS, qmax of clomipramine was 0.053 mg/mg AC and 0.572 mg/mg SPS, and qmax of doxepin was 0.045 mg/mg AC and 0.556 mg/mg SPS. The results of adsorption experiments with SPS revealed higher values for the qmax parameters in comparison with AC.
Conclusion
In vitro gastric decontamination experiments for antidepressant amitriptyline, clomipramine, and doxepin showed that SPS has higher qmax values than the corresponding experiments with AC. Therefore, we suggest SPS is a better gastric decontaminating agent for the management of acute TCA intoxication.</description><subject>Adsorbents</subject><subject>Adsorption</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Charcoal</subject><subject>Drugs</subject><subject>Equilibrium</subject><subject>Experiments</subject><subject>Medicinal Chemistry</subject><subject>Pharmaceutical industry</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Pharmacology/Toxicology</subject><subject>Poisoning</subject><subject>Potassium</subject><subject>Prescription drugs</subject><subject>Research Article</subject><subject>Sodium</subject><issn>1560-8115</issn><issn>2008-2231</issn><issn>2008-2231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkk2LFDEQhoMo7jp69iYNgniwd_O9yUUYFr9gwYt7Dunu6pks6aRNusX596addZwRRQIVUnnqJVV5EXpO8AUhSl5SjFVNKSMl1JQ8QOeHzEN0ToTEtSJEnKEnOd9hzBSX9DE6o5wLzDQ5R7frwU3JjdPOuwBvqtbHwY3JDj9PNnRVF7_D6EJluxzTOLkYqhimWOXYuXmoxuh3edolCFDl2fcx2Ameoke99Rme3e8rdPv-3Zfrj_XN5w-frtc3dSuFnmotGDRAiOWgAVprFZG97kjDwXLdaVsoKiyz0LVKlchtJ7hsmkZeMaFatkJv97rj3AwFgjAl682Y3GDTzkTrzOlNcFuzid8M05hyxorA63uBFL_OkCczuNyC9zZAnLMhglDGqJTy_yjX9IpoKUlBX_6B3sU5hTKJIogZ1lxJ_JvaWA_GhT6WJ7aLqFkLTqhQurS5Qhd_ocrqYHBtDNC7kj8peHVUsAXrp22Ofl5-Lp-Cl3uwTTHnBP1hbgSbxV1m8ZJZvFSCoUtfL47HfeB_2akAeA_kchU2kI4a_4fmDw9g2RQ</recordid><startdate>20140122</startdate><enddate>20140122</enddate><creator>Jamshidzadeh, Akram</creator><creator>Vahedi, Fatemeh</creator><creator>Farshad, Omid</creator><creator>Seradj, Hassan</creator><creator>Najibi, Asma</creator><creator>Dehghanzadeh, Gholamreza</creator><general>BioMed Central</general><general>BioMed Central Ltd</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PADUT</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20140122</creationdate><title>Amitriptyline, clomipramine, and doxepin adsorption onto sodium polystyrene sulfonate</title><author>Jamshidzadeh, Akram ; Vahedi, Fatemeh ; Farshad, Omid ; Seradj, Hassan ; Najibi, Asma ; Dehghanzadeh, Gholamreza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c659t-953ebe11a4e9eecaa816f9d1b4ea49d9a65925a3aedc88aed4ad546bbb67358c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adsorbents</topic><topic>Adsorption</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Charcoal</topic><topic>Drugs</topic><topic>Equilibrium</topic><topic>Experiments</topic><topic>Medicinal Chemistry</topic><topic>Pharmaceutical industry</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Pharmacology/Toxicology</topic><topic>Poisoning</topic><topic>Potassium</topic><topic>Prescription drugs</topic><topic>Research Article</topic><topic>Sodium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jamshidzadeh, Akram</creatorcontrib><creatorcontrib>Vahedi, Fatemeh</creatorcontrib><creatorcontrib>Farshad, Omid</creatorcontrib><creatorcontrib>Seradj, Hassan</creatorcontrib><creatorcontrib>Najibi, Asma</creatorcontrib><creatorcontrib>Dehghanzadeh, Gholamreza</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>Research Library China</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Daru</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jamshidzadeh, Akram</au><au>Vahedi, Fatemeh</au><au>Farshad, Omid</au><au>Seradj, Hassan</au><au>Najibi, Asma</au><au>Dehghanzadeh, Gholamreza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amitriptyline, clomipramine, and doxepin adsorption onto sodium polystyrene sulfonate</atitle><jtitle>Daru</jtitle><stitle>DARU J Pharm Sci</stitle><addtitle>Daru</addtitle><date>2014-01-22</date><risdate>2014</risdate><volume>22</volume><issue>1</issue><spage>21</spage><epage>21</epage><pages>21-21</pages><artnum>21</artnum><issn>1560-8115</issn><issn>2008-2231</issn><eissn>2008-2231</eissn><abstract>Purpose of the study
Comparative in vitro studies were carried out to determine the adsorption characteristics of 3 drugs on activated charcoal (AC) and sodium polystyrene sulfonate (SPS). Activated charcoal (AC) has been long used as gastric decontamination agent for tricyclic antidepressants (TCA).
Methods
Solutions containing drugs (amitriptyline, clomipramine, or doxepin) and variable amount of AC or SPS were incubated for 30 minutes.
Results
At pH 1.2 the adsorbent: drug mass ratio varied from 2 : 1 to 40 : 1 for AC, and from 0.4 : 1 to 8 : 1 for SPS. UV–VIS spectrophotometer was used for the determination of free drug concentrations. The qmax of amitriptyline was 0.055 mg/mg AC and 0.574 mg/mg SPS, qmax of clomipramine was 0.053 mg/mg AC and 0.572 mg/mg SPS, and qmax of doxepin was 0.045 mg/mg AC and 0.556 mg/mg SPS. The results of adsorption experiments with SPS revealed higher values for the qmax parameters in comparison with AC.
Conclusion
In vitro gastric decontamination experiments for antidepressant amitriptyline, clomipramine, and doxepin showed that SPS has higher qmax values than the corresponding experiments with AC. Therefore, we suggest SPS is a better gastric decontaminating agent for the management of acute TCA intoxication.</abstract><cop>London</cop><pub>BioMed Central</pub><pmid>24450391</pmid><doi>10.1186/2008-2231-22-21</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Daru, 2014-01, Vol.22 (1), p.21-21, Article 21 |
| issn | 1560-8115 2008-2231 2008-2231 |
| language | eng |
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| subjects | Adsorbents Adsorption Biomedical and Life Sciences Biomedicine Charcoal Drugs Equilibrium Experiments Medicinal Chemistry Pharmaceutical industry Pharmaceutical Sciences/Technology Pharmacology/Toxicology Poisoning Potassium Prescription drugs Research Article Sodium |
| title | Amitriptyline, clomipramine, and doxepin adsorption onto sodium polystyrene sulfonate |
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