Synthetic Self-Assembling Clostridial Chimera for Modulation of Sensory Functions

Clostridial neurotoxins reversibly block neuronal communication for weeks and months. While these proteolytic neurotoxins hold great promise for clinical applications and the investigation of brain function, their paralytic activity at neuromuscular junctions is a stumbling block. To redirect the cl...

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Veröffentlicht in:	Bioconjugate chemistry 2013-10, Vol.24 (10), p.1750-1759
Hauptverfasser:	Ferrari, Enrico, Gu, Chunjing, Niranjan, Dhevahi, Restani, Laura, Rasetti-Escargueil, Christine, Obara, Ilona, Geranton, Sandrine M, Arsenault, Jason, Goetze, Tom A, Harper, Callista B, Nguyen, Tam H, Maywood, Elizabeth, O’Brien, John, Schiavo, Giampietro, Wheeler, Daniel W, Meunier, Frederic A, Hastings, Michael, Edwardson, J. Michael, Sesardic, Dorothea, Caleo, Matteo, Hunt, Stephen P, Davletov, Bazbek
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteriology Botulinum Toxins, Type A - administration & dosage Botulinum Toxins, Type A - metabolism Brain Brain - drug effects Brain - physiology Cells, Cultured Clostridium botulinum - metabolism Clostridium tetani - metabolism Life Sciences Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Microbiology and Parasitology Models, Molecular Molecules Neurons Neurons - cytology Neurons - drug effects Pain Threshold - drug effects Proteases Proteins Rats Recombinant Fusion Proteins - administration & dosage Recombinant Fusion Proteins - metabolism Tetanus Toxin - administration & dosage Tetanus Toxin - metabolism Toxins
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