Measurement of the toughness of bone: A tutorial with special reference to small animal studies
Abstract Quantitative assessment of the strength and toughness of bone has become an integral part of many biological and bioengineering studies on the structural properties of bone and their degradation due to aging, disease and therapeutic treatment. Whereas the biomechanical techniques for charac...
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| Veröffentlicht in: | Bone (New York, N.Y.) N.Y.), 2008-11, Vol.43 (5), p.798-812 |
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| creator | Ritchie, R.O Koester, K.J Ionova, S Yao, W Lane, N.E Ager, J.W |
| description | Abstract Quantitative assessment of the strength and toughness of bone has become an integral part of many biological and bioengineering studies on the structural properties of bone and their degradation due to aging, disease and therapeutic treatment. Whereas the biomechanical techniques for characterizing bone strength are well documented, few studies have focused on the theory, methodology, and various experimental procedures for evaluating the fracture toughness of bone, i.e., its resistance to fracture, with particular reference to whole bone testing in small animal studies. In this tutorial, we consider the many techniques for evaluating toughness and assess their specific relevance and application to the mechanical testing of small animal bones. Parallel experimental studies on wild-type rat and mouse femurs are used to evaluate the utility of these techniques and specifically to determine the coefficient of variation of the measured toughness values. |
| doi_str_mv | 10.1016/j.bone.2008.04.027 |
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Whereas the biomechanical techniques for characterizing bone strength are well documented, few studies have focused on the theory, methodology, and various experimental procedures for evaluating the fracture toughness of bone, i.e., its resistance to fracture, with particular reference to whole bone testing in small animal studies. In this tutorial, we consider the many techniques for evaluating toughness and assess their specific relevance and application to the mechanical testing of small animal bones. Parallel experimental studies on wild-type rat and mouse femurs are used to evaluate the utility of these techniques and specifically to determine the coefficient of variation of the measured toughness values.</description><identifier>ISSN: 8756-3282</identifier><identifier>EISSN: 1873-2763</identifier><identifier>DOI: 10.1016/j.bone.2008.04.027</identifier><identifier>PMID: 18647665</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Biomechanical Phenomena ; Bone ; Bone and Bones - anatomy & histology ; Crack-resistance curves ; Elasticity ; Fracture toughness ; Fractures, Bone ; Fundamental and applied biological sciences. Psychology ; Humans ; Injuries of the limb. Injuries of the spine ; Mathematics ; Medical sciences ; Models, Anatomic ; Orthopedics ; Small animal models ; Strength ; Stress, Mechanical ; Tensile Strength ; Traumas. 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Whereas the biomechanical techniques for characterizing bone strength are well documented, few studies have focused on the theory, methodology, and various experimental procedures for evaluating the fracture toughness of bone, i.e., its resistance to fracture, with particular reference to whole bone testing in small animal studies. In this tutorial, we consider the many techniques for evaluating toughness and assess their specific relevance and application to the mechanical testing of small animal bones. Parallel experimental studies on wild-type rat and mouse femurs are used to evaluate the utility of these techniques and specifically to determine the coefficient of variation of the measured toughness values.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomechanical Phenomena</subject><subject>Bone</subject><subject>Bone and Bones - anatomy & histology</subject><subject>Crack-resistance curves</subject><subject>Elasticity</subject><subject>Fracture toughness</subject><subject>Fractures, Bone</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Injuries of the limb. Injuries of the spine</subject><subject>Mathematics</subject><subject>Medical sciences</subject><subject>Models, Anatomic</subject><subject>Orthopedics</subject><subject>Small animal models</subject><subject>Strength</subject><subject>Stress, Mechanical</subject><subject>Tensile Strength</subject><subject>Traumas. 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| subjects | Animals Biological and medical sciences Biomechanical Phenomena Bone Bone and Bones - anatomy & histology Crack-resistance curves Elasticity Fracture toughness Fractures, Bone Fundamental and applied biological sciences. Psychology Humans Injuries of the limb. Injuries of the spine Mathematics Medical sciences Models, Anatomic Orthopedics Small animal models Strength Stress, Mechanical Tensile Strength Traumas. Diseases due to physical agents Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Measurement of the toughness of bone: A tutorial with special reference to small animal studies |
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