A cellular system for quantitation of vitamin K cycle activity: structure-activity effects on vitamin K antagonism by warfarin metabolites

Warfarin and other 4-hydroxycoumarins inhibit vitamin K epoxide reductase (VKOR) by depleting reduced vitamin K that is required for posttranslational modification of vitamin K–dependent clotting factors. In vitro prediction of the in vivo potency of vitamin K antagonists is complicated by the compl...

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Veröffentlicht in:	Blood 2014-01, Vol.123 (4), p.582-589
Hauptverfasser:	Haque, Jamil A., McDonald, Matthew G., Kulman, John D., Rettie, Allan E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohols - chemistry Anticoagulants - chemistry Doxycycline - chemistry Factor IX - chemistry Flow Cytometry HEK293 Cells Humans Inhibitory Concentration 50 Liver - metabolism Phenol - chemistry Protein Binding Protein Structure, Tertiary Stereoisomerism Structure-Activity Relationship Thrombosis and Hemostasis Vitamin K - antagonists & inhibitors Vitamin K - chemistry Vitamin K - metabolism Vitamin K Epoxide Reductases - antagonists & inhibitors Vitamin K Epoxide Reductases - metabolism Warfarin - analogs & derivatives Warfarin - chemistry
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