Thrifty metabolic programming in rats is induced by both maternal undernutrition and postnatal leptin treatment, but masked in the presence of both: implications for models of developmental programming

Maternal undernutrition leads to an increased risk of metabolic disorders in offspring including obesity and insulin resistance, thought to be due to a programmed thrifty phenotype which is inappropriate for a subsequent richer nutritional environment. In a rat model, both male and female offspring...

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Veröffentlicht in:	BMC genomics 2014-01, Vol.15 (1), p.49-49, Article 49
Hauptverfasser:	Ellis, Peter J I, Morris, Tiffany J, Skinner, Benjamin M, Sargent, Carole A, Vickers, Mark H, Gluckman, Peter D, Gilmour, Stewart, Affara, Nabeel A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Amino Acids - metabolism Analysis Animals Antigens Carbohydrate metabolism Carbohydrate Metabolism - genetics Colleges & universities Complications and side effects Data processing Diet Disease Models, Animal Female Females Fetal Development Fetal Nutrition Disorders - genetics Fetal Nutrition Disorders - metabolism Fetal Nutrition Disorders - pathology Genetic transcription Genomics Health aspects Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - metabolism Immune system Inflammation Mediators - metabolism Insulin resistance Leptin Leptin - pharmacology Liver - drug effects Liver - metabolism Male Medical research Metabolic disorders Methods Nutrition research Obesity - metabolism Obesity - pathology Oxidative Stress - genetics Phenotype Physiological aspects Plasma Pregnancy Rats Rats, Wistar Risk factors Rodents Transcriptome - drug effects
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