Identification of a Major Determinant for Serine-Threonine Kinase Phosphoacceptor Specificity

Eukaryotic protein kinases are generally classified as being either tyrosine or serine-threonine specific. Though not evident from inspection of their primary sequences, many serine-threonine kinases display a significant preference for serine or threonine as the phosphoacceptor residue. Here we sho...

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Veröffentlicht in:	Mol. Cell 2014-01, Vol.53 (1), p.140-147
Hauptverfasser:	Chen, Catherine, Ha, Byung Hak, Thévenin, Anastasia F., Lou, Hua Jane, Zhang, Rong, Yip, Kevin Y., Peterson, Jeffrey R., Gerstein, Mark, Kim, Philip M., Filippakopoulos, Panagis, Knapp, Stefan, Boggon, Titus J., Turk, Benjamin E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites catalytic activity crystal structure Crystallography, X-Ray HEK293 Cells Humans Kinetics mutation p21-Activated Kinases - chemistry p21-Activated Kinases - genetics p21-Activated Kinases - metabolism Peptides - chemistry Peptides - genetics Peptides - metabolism Phosphorylation protein kinases Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism serine Short Substrate Specificity - physiology threonine tyrosine
Online-Zugang:	Volltext
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