Exploiting functional domains of GRK2/3 to alter the competitive balance of pro‐ and anticontractile signaling in airway smooth muscle

To clarify the potential utility of targeting GRK2/3‐mediated desensitization as a means of manipulating airway smooth muscle (ASM) contractile state, we assessed the specificity of GRK2/3 regulation of procontractile and relaxant G‐protein‐coupled receptors in ASM. Functional domains of GRK2/3 were...

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Veröffentlicht in:The FASEB journal 2014-02, Vol.28 (2), p.956-965
Hauptverfasser: Deshpande, Deepak A., Yan, Huandong, Kong, Kok‐Choi, Tiegs, Brian C., Morgan, Sarah J., Pera, Tonio, Panettieri, Reynold A., Eckhart, Andrea D., Penn, Raymond B.
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Sprache:eng
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