PPM1A is a RelA phosphatase with tumor suppressor-like activity

Nuclear factor-κB (NF-κB) signaling contributes to human disease processes, notably inflammatory diseases and cancer. NF-κB has a role in tumorigenesis and tumor growth, as well as promotion of metastases. Mechanisms responsible for abnormal NF-κB activation are not fully elucidated; however, RelA p...

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Veröffentlicht in:	Oncogene 2014-05, Vol.33 (22), p.2918-2927
Hauptverfasser:	Lu, X, An, H, Jin, R, Zou, M, Guo, Y, Su, P-F, Liu, D, Shyr, Y, Yarbrough, W G
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/516/1909 631/67/322 631/67/589/466 631/80/86 Animals Apoptosis Cell Biology Cell Line, Tumor Cell Movement - genetics Cell Nucleus - metabolism Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Chemokines Control Disease Models, Animal Enzymes Gene Expression Genetic aspects Genetics Heterografts Human Genetics Humans Inflammatory diseases Interleukin 6 Internal Medicine Kinases Male Medicine Medicine & Public Health Metastases Metastasis Mice Monocyte chemoattractant protein 1 Monocytes Neoplasm Metastasis Neoplastic processes NF-kappa B - metabolism NF-κB protein Oncology original-article Phosphatase Phosphatases Phosphoprotein phosphatase Phosphoprotein Phosphatases - metabolism Phosphorylation Properties Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Protein Binding Protein phosphatase Protein Phosphatase 2C Protein Transport Proteins RelA protein Transcription Transcription Factor RelA - genetics Transcription Factor RelA - metabolism Transcription factors Transcription, Genetic Tumor Necrosis Factor-alpha - metabolism Tumor suppressor genes Tumor Suppressor Proteins - metabolism Tumorigenesis Tumors
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