Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus

The TNFAIP3 (tumor necrosis factor alpha-induced protein 3) gene encodes a ubiquitin editing enzyme, A20, that restricts NF-κB-dependent signaling and prevents inflammation. We show that three independent SNPs in the TNFAIP3 region (rs13192841, rs2230926 and rs6922466) are associated with systemic l...

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Veröffentlicht in:	Nature genetics 2008-09, Vol.40 (9), p.1062-1064
Hauptverfasser:	Gregersen, Peter K, Petri, Michelle A, Kwok, Pui-Yan, Musone, Stacy L, Taylor, Kimberly E, Seldin, Michael F, Ferreira, Ricardo C, Shifrin, Nataliya, Lu, Timothy T, Criswell, Lindsey A, Ilyas Kamboh, M, Behrens, Timothy W, Manzi, Susan, Ma, Averil, Nititham, Joanne, Ortmann, Ward
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Apoptosis Autoimmune diseases Biological and medical sciences Biomedical and Life Sciences Biomedicine brief-communication Cancer Research Cellular proteins DNA-Binding Proteins Fundamental and applied biological sciences. Psychology Gene Function Genetic aspects Genetic Predisposition to Disease Genetic testing Genetics of eukaryotes. Biological and molecular evolution Health aspects Health services Human Genetics Humans Intracellular Signaling Peptides and Proteins - genetics Lupus Lupus Erythematosus, Systemic - genetics Medical sciences Minority & ethnic groups Nuclear Proteins - genetics Polymorphism Polymorphism, Single Nucleotide Principal components analysis Quality control Rheumatoid arthritis Risk factors Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Single nucleotide polymorphisms Systemic lupus erythematosus Tumor Necrosis Factor alpha-Induced Protein 3 White People - genetics
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Beschreibung
Zusammenfassung:	The TNFAIP3 (tumor necrosis factor alpha-induced protein 3) gene encodes a ubiquitin editing enzyme, A20, that restricts NF-κB-dependent signaling and prevents inflammation. We show that three independent SNPs in the TNFAIP3 region (rs13192841, rs2230926 and rs6922466) are associated with systemic lupus erythematosus (SLE) among individuals of European ancestry. These findings provide critical links between A20 and the etiology of SLE.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/ng.202