A preliminary investigation of anticholinesterase activity of some Iranian medicinal plants commonly used in traditional medicine
Background The aim of this study was to evaluate acetylcholinesterase inhibitory activity of some commonly used herbal medicine in Iran to introduce a new source for management of Alzheimer’s disease. A total of 18 aqueous-methanolic extract (1:1; v/v) from the following plants: Brassica alba , Bras...
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| Veröffentlicht in: | Daru 2014-01, Vol.22 (1), p.17-17, Article 17 |
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| creator | Jazayeri, Seyed Behzad Amanlou, Arash Ghanadian, Naghmeh Pasalar, Parvin Amanlou, Massoud |
| description | Background
The aim of this study was to evaluate acetylcholinesterase inhibitory activity of some commonly used herbal medicine in Iran to introduce a new source for management of Alzheimer’s disease. A total of 18 aqueous-methanolic extract (1:1; v/v) from the following plants:
Brassica alba
,
Brassica nigra
,
Camellia sinensis
,
Cinchona officinalis
,
Citrus aurantifolia
,
Citrus x aurantium
,
Ferula assafoetida
,
Humulus lupulus
,
Juglans regia
,
Juniperus sabina
,
Myristica fragrans
,
Pelargonium graveolens
,
Pistacia vera
,
Punica granatum
,
Rheum officinale
,
Rosa damascena
,
Salix alba
,
and Zizyphus vulgaris
were prepared and screened for their acetylcholinesterase inhibitory activity using
in vitro
Ellman spectrophotometric method.
Results
According to the obtained results, the order of inhibitory activity (IC
50
values, μg /ml) of extracts from highest to the lowest was:
C. sinensis
(5.96),
C. aurantifolia
(19.57),
Z. vulgaris
(24.37),
B. nigra
(84.30) and
R. damascena
(93.1).
Conclusions
The results indicated and confirmed the traditional use of these herbs for management of central nervous system disorders.
C. sinensis
showed the highest activity in inhibition of acetylcholinesterase. However, further investigations on identification of active components in the extracts are needed. |
| doi_str_mv | 10.1186/2008-2231-22-17 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3896674</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A541259379</galeid><sourcerecordid>A541259379</sourcerecordid><originalsourceid>FETCH-LOGICAL-c593t-55e8ee70317a0b313c53781bd8fca016d478b4bcdc266791f07a594afeee9db3</originalsourceid><addsrcrecordid>eNqFkkuL2zAQgE1p6Wa3PfdWDIWyF-_qYdnypRCWPhYWetm7kOVxokWWUskO5Lj_vGOSpklpKQYZZr75rBlPlr2j5IZSWd0yQmTBGKd4FLR-kS2OkZfZgoqKFJJScZFdpvRECJdlxV5nF6wsCRWcLbLnZb6J4OxgvY673PotpNGu9GiDz0Ofaz9asw7OeoxD1AlybUa7teNuTqcwQH4ftbfa5wN01qDH5RuHdSk3YRiCd7t8StChOx-j7uysRuZAw5vsVa9dgreH91X2-OXz49234uH71_u75UNhRMPHQgiQADXhtNak5ZQbwWtJ2072RhNadWUt27I1nWFVVTe0J7UWTal7AGi6ll9ln_bazdTipw14vIxTm2gHbFwFbdV5xtu1WoWt4rJBYYmC64Mghh8TTkMNNhlw2CqEKSkqKOOcCcn-j5YNkY0UpEb0wx_oU5gizmcWEk6aUlbiN7XSDpT1fcArmlmqlqKkDCdUN0jd_IXCp4PBmuChtxg_K_h4UrAG7cZ1Cm6a_1A6B2_3oIkhpQj9cW6UqHkR1bx2al47PBSd-3p_Ou4j_2vzECB7IGHKryCeNP4P50-Zduhw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1503094865</pqid></control><display><type>article</type><title>A preliminary investigation of anticholinesterase activity of some Iranian medicinal plants commonly used in traditional medicine</title><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><source>SpringerLink Journals - AutoHoldings</source><creator>Jazayeri, Seyed Behzad ; Amanlou, Arash ; Ghanadian, Naghmeh ; Pasalar, Parvin ; Amanlou, Massoud</creator><creatorcontrib>Jazayeri, Seyed Behzad ; Amanlou, Arash ; Ghanadian, Naghmeh ; Pasalar, Parvin ; Amanlou, Massoud</creatorcontrib><description>Background
The aim of this study was to evaluate acetylcholinesterase inhibitory activity of some commonly used herbal medicine in Iran to introduce a new source for management of Alzheimer’s disease. A total of 18 aqueous-methanolic extract (1:1; v/v) from the following plants:
Brassica alba
,
Brassica nigra
,
Camellia sinensis
,
Cinchona officinalis
,
Citrus aurantifolia
,
Citrus x aurantium
,
Ferula assafoetida
,
Humulus lupulus
,
Juglans regia
,
Juniperus sabina
,
Myristica fragrans
,
Pelargonium graveolens
,
Pistacia vera
,
Punica granatum
,
Rheum officinale
,
Rosa damascena
,
Salix alba
,
and Zizyphus vulgaris
were prepared and screened for their acetylcholinesterase inhibitory activity using
in vitro
Ellman spectrophotometric method.
Results
According to the obtained results, the order of inhibitory activity (IC
50
values, μg /ml) of extracts from highest to the lowest was:
C. sinensis
(5.96),
C. aurantifolia
(19.57),
Z. vulgaris
(24.37),
B. nigra
(84.30) and
R. damascena
(93.1).
Conclusions
The results indicated and confirmed the traditional use of these herbs for management of central nervous system disorders.
C. sinensis
showed the highest activity in inhibition of acetylcholinesterase. However, further investigations on identification of active components in the extracts are needed.</description><identifier>ISSN: 1560-8115</identifier><identifier>ISSN: 2008-2231</identifier><identifier>EISSN: 2008-2231</identifier><identifier>DOI: 10.1186/2008-2231-22-17</identifier><identifier>PMID: 24401532</identifier><language>eng</language><publisher>London: BioMed Central</publisher><subject>Activities of daily living ; Biomedical and Life Sciences ; Biomedicine ; Brain research ; Brassica nigra ; Enzyme inhibitors ; Enzyme kinetics ; Health aspects ; Herbal medicine ; Medicinal Chemistry ; Medicinal plants ; Nervous system diseases ; Pharmaceutical Sciences/Technology ; Pharmacology/Toxicology ; Regulatory approval ; Short Communication ; Statistical analysis ; Statistical methods ; Studies</subject><ispartof>Daru, 2014-01, Vol.22 (1), p.17-17, Article 17</ispartof><rights>Jazayeri et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated.</rights><rights>COPYRIGHT 2014 BioMed Central Ltd.</rights><rights>Copyright Tehran University of Medical Sciences Publications Jan 2014</rights><rights>Copyright © 2014 Jazayeri et al.; licensee BioMed Central Ltd. 2014 Jazayeri et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-55e8ee70317a0b313c53781bd8fca016d478b4bcdc266791f07a594afeee9db3</citedby><cites>FETCH-LOGICAL-c593t-55e8ee70317a0b313c53781bd8fca016d478b4bcdc266791f07a594afeee9db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896674/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896674/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24401532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jazayeri, Seyed Behzad</creatorcontrib><creatorcontrib>Amanlou, Arash</creatorcontrib><creatorcontrib>Ghanadian, Naghmeh</creatorcontrib><creatorcontrib>Pasalar, Parvin</creatorcontrib><creatorcontrib>Amanlou, Massoud</creatorcontrib><title>A preliminary investigation of anticholinesterase activity of some Iranian medicinal plants commonly used in traditional medicine</title><title>Daru</title><addtitle>DARU J Pharm Sci</addtitle><addtitle>Daru</addtitle><description>Background
The aim of this study was to evaluate acetylcholinesterase inhibitory activity of some commonly used herbal medicine in Iran to introduce a new source for management of Alzheimer’s disease. A total of 18 aqueous-methanolic extract (1:1; v/v) from the following plants:
Brassica alba
,
Brassica nigra
,
Camellia sinensis
,
Cinchona officinalis
,
Citrus aurantifolia
,
Citrus x aurantium
,
Ferula assafoetida
,
Humulus lupulus
,
Juglans regia
,
Juniperus sabina
,
Myristica fragrans
,
Pelargonium graveolens
,
Pistacia vera
,
Punica granatum
,
Rheum officinale
,
Rosa damascena
,
Salix alba
,
and Zizyphus vulgaris
were prepared and screened for their acetylcholinesterase inhibitory activity using
in vitro
Ellman spectrophotometric method.
Results
According to the obtained results, the order of inhibitory activity (IC
50
values, μg /ml) of extracts from highest to the lowest was:
C. sinensis
(5.96),
C. aurantifolia
(19.57),
Z. vulgaris
(24.37),
B. nigra
(84.30) and
R. damascena
(93.1).
Conclusions
The results indicated and confirmed the traditional use of these herbs for management of central nervous system disorders.
C. sinensis
showed the highest activity in inhibition of acetylcholinesterase. However, further investigations on identification of active components in the extracts are needed.</description><subject>Activities of daily living</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain research</subject><subject>Brassica nigra</subject><subject>Enzyme inhibitors</subject><subject>Enzyme kinetics</subject><subject>Health aspects</subject><subject>Herbal medicine</subject><subject>Medicinal Chemistry</subject><subject>Medicinal plants</subject><subject>Nervous system diseases</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Pharmacology/Toxicology</subject><subject>Regulatory approval</subject><subject>Short Communication</subject><subject>Statistical analysis</subject><subject>Statistical methods</subject><subject>Studies</subject><issn>1560-8115</issn><issn>2008-2231</issn><issn>2008-2231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkkuL2zAQgE1p6Wa3PfdWDIWyF-_qYdnypRCWPhYWetm7kOVxokWWUskO5Lj_vGOSpklpKQYZZr75rBlPlr2j5IZSWd0yQmTBGKd4FLR-kS2OkZfZgoqKFJJScZFdpvRECJdlxV5nF6wsCRWcLbLnZb6J4OxgvY673PotpNGu9GiDz0Ofaz9asw7OeoxD1AlybUa7teNuTqcwQH4ftbfa5wN01qDH5RuHdSk3YRiCd7t8StChOx-j7uysRuZAw5vsVa9dgreH91X2-OXz49234uH71_u75UNhRMPHQgiQADXhtNak5ZQbwWtJ2072RhNadWUt27I1nWFVVTe0J7UWTal7AGi6ll9ln_bazdTipw14vIxTm2gHbFwFbdV5xtu1WoWt4rJBYYmC64Mghh8TTkMNNhlw2CqEKSkqKOOcCcn-j5YNkY0UpEb0wx_oU5gizmcWEk6aUlbiN7XSDpT1fcArmlmqlqKkDCdUN0jd_IXCp4PBmuChtxg_K_h4UrAG7cZ1Cm6a_1A6B2_3oIkhpQj9cW6UqHkR1bx2al47PBSd-3p_Ou4j_2vzECB7IGHKryCeNP4P50-Zduhw</recordid><startdate>20140108</startdate><enddate>20140108</enddate><creator>Jazayeri, Seyed Behzad</creator><creator>Amanlou, Arash</creator><creator>Ghanadian, Naghmeh</creator><creator>Pasalar, Parvin</creator><creator>Amanlou, Massoud</creator><general>BioMed Central</general><general>BioMed Central Ltd</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PADUT</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20140108</creationdate><title>A preliminary investigation of anticholinesterase activity of some Iranian medicinal plants commonly used in traditional medicine</title><author>Jazayeri, Seyed Behzad ; Amanlou, Arash ; Ghanadian, Naghmeh ; Pasalar, Parvin ; Amanlou, Massoud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-55e8ee70317a0b313c53781bd8fca016d478b4bcdc266791f07a594afeee9db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Activities of daily living</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain research</topic><topic>Brassica nigra</topic><topic>Enzyme inhibitors</topic><topic>Enzyme kinetics</topic><topic>Health aspects</topic><topic>Herbal medicine</topic><topic>Medicinal Chemistry</topic><topic>Medicinal plants</topic><topic>Nervous system diseases</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Pharmacology/Toxicology</topic><topic>Regulatory approval</topic><topic>Short Communication</topic><topic>Statistical analysis</topic><topic>Statistical methods</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jazayeri, Seyed Behzad</creatorcontrib><creatorcontrib>Amanlou, Arash</creatorcontrib><creatorcontrib>Ghanadian, Naghmeh</creatorcontrib><creatorcontrib>Pasalar, Parvin</creatorcontrib><creatorcontrib>Amanlou, Massoud</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Research Library China</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Daru</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jazayeri, Seyed Behzad</au><au>Amanlou, Arash</au><au>Ghanadian, Naghmeh</au><au>Pasalar, Parvin</au><au>Amanlou, Massoud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A preliminary investigation of anticholinesterase activity of some Iranian medicinal plants commonly used in traditional medicine</atitle><jtitle>Daru</jtitle><stitle>DARU J Pharm Sci</stitle><addtitle>Daru</addtitle><date>2014-01-08</date><risdate>2014</risdate><volume>22</volume><issue>1</issue><spage>17</spage><epage>17</epage><pages>17-17</pages><artnum>17</artnum><issn>1560-8115</issn><issn>2008-2231</issn><eissn>2008-2231</eissn><abstract>Background
The aim of this study was to evaluate acetylcholinesterase inhibitory activity of some commonly used herbal medicine in Iran to introduce a new source for management of Alzheimer’s disease. A total of 18 aqueous-methanolic extract (1:1; v/v) from the following plants:
Brassica alba
,
Brassica nigra
,
Camellia sinensis
,
Cinchona officinalis
,
Citrus aurantifolia
,
Citrus x aurantium
,
Ferula assafoetida
,
Humulus lupulus
,
Juglans regia
,
Juniperus sabina
,
Myristica fragrans
,
Pelargonium graveolens
,
Pistacia vera
,
Punica granatum
,
Rheum officinale
,
Rosa damascena
,
Salix alba
,
and Zizyphus vulgaris
were prepared and screened for their acetylcholinesterase inhibitory activity using
in vitro
Ellman spectrophotometric method.
Results
According to the obtained results, the order of inhibitory activity (IC
50
values, μg /ml) of extracts from highest to the lowest was:
C. sinensis
(5.96),
C. aurantifolia
(19.57),
Z. vulgaris
(24.37),
B. nigra
(84.30) and
R. damascena
(93.1).
Conclusions
The results indicated and confirmed the traditional use of these herbs for management of central nervous system disorders.
C. sinensis
showed the highest activity in inhibition of acetylcholinesterase. However, further investigations on identification of active components in the extracts are needed.</abstract><cop>London</cop><pub>BioMed Central</pub><pmid>24401532</pmid><doi>10.1186/2008-2231-22-17</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1560-8115 |
| ispartof | Daru, 2014-01, Vol.22 (1), p.17-17, Article 17 |
| issn | 1560-8115 2008-2231 2008-2231 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3896674 |
| source | EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry; SpringerLink Journals - AutoHoldings |
| subjects | Activities of daily living Biomedical and Life Sciences Biomedicine Brain research Brassica nigra Enzyme inhibitors Enzyme kinetics Health aspects Herbal medicine Medicinal Chemistry Medicinal plants Nervous system diseases Pharmaceutical Sciences/Technology Pharmacology/Toxicology Regulatory approval Short Communication Statistical analysis Statistical methods Studies |
| title | A preliminary investigation of anticholinesterase activity of some Iranian medicinal plants commonly used in traditional medicine |
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