Bifunctional Ligands Allow Deliberate Extrinsic Reprogramming of the Glucocorticoid Receptor

Therapies based on conventional nuclear receptor ligands are extremely powerful, yet their broad and long-term use is often hindered by undesired side effects that are often part of the receptor's biological function. Selective control of nuclear receptors such as the glucocorticoid receptor (G...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2014-02, Vol.28 (2), p.249-259
Hauptverfasser:	Højfeldt, Jonas W, Cruz-Rodríguez, Osvaldo, Imaeda, Yasuhiro, Van Dyke, Aaron R, Carolan, James P, Mapp, Anna K, Iñiguez-Lluhí, Jorge A
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Dexamethasone - pharmacology HEK293 Cells Histone Deacetylase 1 - metabolism Humans Ligands Mifepristone - pharmacology Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Original Research Protein Binding Receptors, Glucocorticoid - agonists Receptors, Glucocorticoid - antagonists & inhibitors Receptors, Glucocorticoid - physiology Tacrolimus - pharmacology Transcriptional Activation
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