Potent hyperglycemic and hyperinsulinemic effects of thyrotropin-releasing hormone microinjected into the rostroventrolateral medulla and abnormal responses in type 2 diabetic rats

Abstract We identified ventrolateral medullary nuclei in which thyrotropin-releasing hormone (TRH) regulates glucose metabolism by modulating autonomic activity. Immunolabeling revealed dense prepro-TRH-containing fibers innervating the rostroventrolateral medulla (RVLM) and nucleus ambiguus (Amb),...

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Veröffentlicht in:	Neuroscience 2010-08, Vol.169 (2), p.706-719
Hauptverfasser:	Ao, Y, Ko, M, Chen, A, Marvizon, J.C, Adelson, D, Song, M.K, Go, V.L.W, Liu, Y.Y, Yang, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Animals Biological and medical sciences Blood Glucose - metabolism brainstem diabetes Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fundamental and applied biological sciences. Psychology glucose Hyperglycemia - metabolism Hyperglycemia - physiopathology Hyperinsulinism - metabolism Hyperinsulinism - physiopathology insulin Insulin - blood Male Medical sciences Medulla Oblongata - drug effects Medulla Oblongata - metabolism Microinjections Nerve Fibers - metabolism Neural Pathways - physiopathology Neurology Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ Protein Precursors - metabolism Pyrrolidonecarboxylic Acid - analogs & derivatives Pyrrolidonecarboxylic Acid - metabolism Pyrrolidonecarboxylic Acid - pharmacology Rats Rats, Wistar Spinal Cord - physiopathology sympathetic Thyrotropin-Releasing Hormone - analogs & derivatives Thyrotropin-Releasing Hormone - metabolism Thyrotropin-Releasing Hormone - pharmacology vagus Vagus Nerve - physiopathology Vertebrates: nervous system and sense organs
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