Intracerebral transplantation of neural stem cells combined with trehalose ingestion alleviates pathology in a mouse model of Huntington's disease

The present investigation examined the neuroprotective benefits for combined trehalose administration with C17.2 neural stem cell transplantation in a transgenic mouse model of Huntington's disease (HD), R6/2. C17.2 neural stem cells have the potential of differentiating into a neuronal phenoty...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of neuroscience research 2009-01, Vol.87 (1), p.26-33
Hauptverfasser:	Yang, Chia-Ron, Yu, Robert K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Analysis of Variance Animals Body Weight - drug effects Body Weight - genetics cell transplantation Corpus Striatum - pathology Disease Models, Animal Hand Strength - physiology Humans Huntingtin Protein Huntington Disease - drug therapy Huntington Disease - mortality Huntington Disease - physiopathology Huntington Disease - surgery Huntington's disease Maze Learning - drug effects Maze Learning - physiology Mice Mice, Transgenic Microarray Analysis - methods Motor Activity - drug effects Motor Activity - physiology Nerve Tissue Proteins - genetics neural stem cell Neurons - physiology Nuclear Proteins - genetics Peptides - metabolism polyglutamine polyQ Psychomotor Performance - drug effects Psychomotor Performance - physiology Stem Cell Transplantation - methods Survival Analysis trehalose Trehalose - administration & dosage Trinucleotide Repeat Expansion - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!