Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice

Post-operative cognitive dysfunction (POCD) is associated with increased cost of care, morbidity and mortality. However, its pathogenesis remains largely to be determined. Specifically, it is unknown why elderly patients are more likely to develop POCD and whether POCD is dependent on general anesth...

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Veröffentlicht in:	Scientific reports 2014-01, Vol.4 (1), p.3766-3766, Article 3766
Hauptverfasser:	Xu, Zhipeng, Dong, Yuanlin, Wang, Hui, Culley, Deborah J., Marcantonio, Edward R., Crosby, Gregory, Tanzi, Rudolph E., Zhang, Yiying, Xie, Zhongcong
Format:	Artikel
Sprache:	eng
Schlagworte:	692/1807/410 692/699/375/365/1283 82/51 82/80 96/106 Abdomen - pathology Abdomen - surgery Accumulation Aged Aging - pathology Alzheimer Disease - etiology Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - biosynthesis Amyloid precursor protein Amyloid Precursor Protein Secretases - antagonists & inhibitors Amyloid Precursor Protein Secretases - metabolism Anesthesia Anesthesia, General - adverse effects Animals Cognition Disorders - complications Cognition Disorders - pathology Cognitive ability Disease Models, Animal Geriatrics Humanities and Social Sciences Humans Mice Mice, Transgenic Morbidity multidisciplinary Neurodegenerative diseases Neuropathology Older people Pathogenesis Point mutation Postoperative Complications - pathology Rodents Science Secretase Surgery Transgenic mice β-Amyloid
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