rhBMP-2 has adverse effects on human oral carcinoma cell lines in vivo

Objectives/Hypothesis: To establish the relevance of the bone morphogenetic protein (BMP) signaling pathway in human oral squamous cell carcinoma (OSCCA) cell lines and determine if there is a biologic impact of stimulating this pathway with recombinant human (rh) BMP‐2. Study Design: In vitro labor...

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Veröffentlicht in:	The Laryngoscope 2012-01, Vol.122 (1), p.95-102
Hauptverfasser:	Kokorina, Natalia A., Lewis Jr, James S., Zakharkin, Stanislav O., Krebsbach, Paul H., Nussenbaum, Brian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bone morphogenetic protein Bone Morphogenetic Protein 2 - adverse effects Bone Morphogenetic Protein 2 - biosynthesis Bone Morphogenetic Protein 2 - genetics Carcinoma, Squamous Cell - chemically induced Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Dermatology Humans Level of Evidence: 5 Medical sciences Mice Mouth Neoplasms - chemically induced Mouth Neoplasms - genetics Mouth Neoplasms - metabolism Neoplasm Transplantation oral cancer Otorhinolaryngology. Stomatology Recombinant Proteins - adverse effects squamous cell carcinoma Transforming Growth Factor beta - adverse effects Tumor Cells, Cultured Tumors Tumors of the skin and soft tissue. Premalignant lesions Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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