Proteome analysis and conditional deletion of the EAAT2 glutamate transporter provide evidence against a role of EAAT2 in pancreatic insulin secretion in mice

Islet function is incompletely understood in part because key steps in glutamate handling remain undetermined. The glutamate (excitatory amino acid) transporter 2 (EAAT2; Slc1a2) has been hypothesized to (a) provide islet cells with glutamate, (b) protect islet cells against high extracellular gluta...

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Veröffentlicht in:	The Journal of biological chemistry 2014-01, Vol.289 (3), p.1329-1344
Hauptverfasser:	Zhou, Yun, Waanders, Leonie F, Holmseth, Silvia, Guo, Caiying, Berger, Urs V, Li, Yuchuan, Lehre, Anne-Catherine, Lehre, Knut P, Danbolt, Niels C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Crosses, Genetic Excitatory Amino Acid Transporter 2 - genetics Excitatory Amino Acid Transporter 2 - metabolism Gene Deletion Glutamic Acid - genetics Glutamic Acid - metabolism Insulin - genetics Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - cytology Insulin-Secreting Cells - metabolism Membrane Biology Mice Mice, Knockout Proteome - genetics Proteome - metabolism
Online-Zugang:	Volltext
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