Helper Activity of Human Leukemic Tissue Extracts for Leukemia Virus Expression in Mice
Extracts of cultured human leukemic tissues increased the spleen focus-forming activity of Friend leukemia virus preparations in BALB/c and other partially resistant mice. Such mice carry the Fv-1bgene, which inhibits the expression of helper virus indigenous to the Friend virus complex, and allows...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1971-10, Vol.68 (10), p.2391-2395 |
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| container_issue | 10 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 68 |
| creator | Steeves, Richard A. Fjelde, Audrey Mirand, Edwin A. |
| description | Extracts of cultured human leukemic tissues increased the spleen focus-forming activity of Friend leukemia virus preparations in BALB/c and other partially resistant mice. Such mice carry the Fv-1bgene, which inhibits the expression of helper virus indigenous to the Friend virus complex, and allows co-infecting leukemia viruses of mice, cats, or chickens to substitute for the inhibited helper virus and increase the expression of the spleen focus-forming virus. The helper activity of extracts from human leukemic tissues shared several important properties with that associated with known leukemogenic viruses of animals. |
| doi_str_mv | 10.1073/pnas.68.10.2391 |
| format | Article |
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Such mice carry the Fv-1bgene, which inhibits the expression of helper virus indigenous to the Friend virus complex, and allows co-infecting leukemia viruses of mice, cats, or chickens to substitute for the inhibited helper virus and increase the expression of the spleen focus-forming virus. 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Such mice carry the Fv-1bgene, which inhibits the expression of helper virus indigenous to the Friend virus complex, and allows co-infecting leukemia viruses of mice, cats, or chickens to substitute for the inhibited helper virus and increase the expression of the spleen focus-forming virus. The helper activity of extracts from human leukemic tissues shared several important properties with that associated with known leukemogenic viruses of animals.</description><subject>Animals</subject><subject>Biological Sciences: Microbiology</subject><subject>Blood Cells - microbiology</subject><subject>Bone Marrow - microbiology</subject><subject>Bone Marrow Cells</subject><subject>Chemical suspensions</subject><subject>Culture Techniques</subject><subject>Cultured cells</subject><subject>Friend murine leukemia virus - growth & development</subject><subject>Helper Viruses</subject><subject>Hodgkin Disease - microbiology</subject><subject>Humans</subject><subject>Leukemia</subject><subject>Leukemia - microbiology</subject><subject>Leukemia Virus, Murine - growth & development</subject><subject>Leukemia, Lymphoid - microbiology</subject><subject>Leukemia, Myeloid - microbiology</subject><subject>Leukemia, Myeloid, Acute - microbiology</subject><subject>Lymph nodes</subject><subject>Lymph Nodes - microbiology</subject><subject>Lymphoma, Large B-Cell, Diffuse - microbiology</subject><subject>Lymphoma, Non-Hodgkin - microbiology</subject><subject>Mice</subject><subject>Polycythemia Vera - microbiology</subject><subject>Spleen</subject><subject>Spleen - microbiology</subject><subject>Spleen focus forming viruses</subject><subject>Tissue culture techniques</subject><subject>Tissue Extracts</subject><subject>Virus Cultivation</subject><subject>Viruses</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFvFCEUxonR1G31bGKi4dSeZgsDw8DBQ9PUbpM1XqoeCcs-lDozjMA07X8vk9229uKJvHy_7_HlfQi9o2RJSctOx8GkpZBlWNZM0RdoQYmileCKvEQLQuq2krzmr9FhSjeEENVIcoAOOGO1pGSBfqygGyHiM5v9rc_3ODi8mnoz4DVMv6H3Fl_7lCbAF3c5GpsTdiE-iAZ_93FKRRsjpOTDgP2Av3gLb9ArZ7oEb_fvEfr2-eL6fFWtv15enZ-tK8sFzRVXxgigtpYNUy2oreCk4Y7YjXOtohu7ldDwErVx0BrKWyPElknCa9fSRkh2hD7t9o7TpoethaGk7PQYfW_ivQ7G6-fK4H_pn-FWM6l4rYr_eO-P4c8EKeveJwtdZwYIU9KS1lw0jBbwdAfaGFKK4B7_oETPVei5Ci3kPM9VFMeHf6M98vvbF_3jXp-ND-qzBSf_BbSbui7DXS7k-x15k3KITyglDWN_AWf9ptM</recordid><startdate>19711001</startdate><enddate>19711001</enddate><creator>Steeves, Richard A.</creator><creator>Fjelde, Audrey</creator><creator>Mirand, Edwin A.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19711001</creationdate><title>Helper Activity of Human Leukemic Tissue Extracts for Leukemia Virus Expression in Mice</title><author>Steeves, Richard A. ; Fjelde, Audrey ; Mirand, Edwin A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-49aa6e1c285397e9d64054f0cbff791bcd8e542815fe7a147a66d38042f715683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Animals</topic><topic>Biological Sciences: Microbiology</topic><topic>Blood Cells - microbiology</topic><topic>Bone Marrow - microbiology</topic><topic>Bone Marrow Cells</topic><topic>Chemical suspensions</topic><topic>Culture Techniques</topic><topic>Cultured cells</topic><topic>Friend murine leukemia virus - growth & development</topic><topic>Helper Viruses</topic><topic>Hodgkin Disease - microbiology</topic><topic>Humans</topic><topic>Leukemia</topic><topic>Leukemia - microbiology</topic><topic>Leukemia Virus, Murine - growth & development</topic><topic>Leukemia, Lymphoid - microbiology</topic><topic>Leukemia, Myeloid - microbiology</topic><topic>Leukemia, Myeloid, Acute - microbiology</topic><topic>Lymph nodes</topic><topic>Lymph Nodes - microbiology</topic><topic>Lymphoma, Large B-Cell, Diffuse - microbiology</topic><topic>Lymphoma, Non-Hodgkin - microbiology</topic><topic>Mice</topic><topic>Polycythemia Vera - microbiology</topic><topic>Spleen</topic><topic>Spleen - microbiology</topic><topic>Spleen focus forming viruses</topic><topic>Tissue culture techniques</topic><topic>Tissue Extracts</topic><topic>Virus Cultivation</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Steeves, Richard A.</creatorcontrib><creatorcontrib>Fjelde, Audrey</creatorcontrib><creatorcontrib>Mirand, Edwin A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Steeves, Richard A.</au><au>Fjelde, Audrey</au><au>Mirand, Edwin A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Helper Activity of Human Leukemic Tissue Extracts for Leukemia Virus Expression in Mice</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1971-10-01</date><risdate>1971</risdate><volume>68</volume><issue>10</issue><spage>2391</spage><epage>2395</epage><pages>2391-2395</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Extracts of cultured human leukemic tissues increased the spleen focus-forming activity of Friend leukemia virus preparations in BALB/c and other partially resistant mice. Such mice carry the Fv-1bgene, which inhibits the expression of helper virus indigenous to the Friend virus complex, and allows co-infecting leukemia viruses of mice, cats, or chickens to substitute for the inhibited helper virus and increase the expression of the spleen focus-forming virus. The helper activity of extracts from human leukemic tissues shared several important properties with that associated with known leukemogenic viruses of animals.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>4332810</pmid><doi>10.1073/pnas.68.10.2391</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1971-10, Vol.68 (10), p.2391-2395 |
| issn | 0027-8424 1091-6490 |
| language | eng |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Biological Sciences: Microbiology Blood Cells - microbiology Bone Marrow - microbiology Bone Marrow Cells Chemical suspensions Culture Techniques Cultured cells Friend murine leukemia virus - growth & development Helper Viruses Hodgkin Disease - microbiology Humans Leukemia Leukemia - microbiology Leukemia Virus, Murine - growth & development Leukemia, Lymphoid - microbiology Leukemia, Myeloid - microbiology Leukemia, Myeloid, Acute - microbiology Lymph nodes Lymph Nodes - microbiology Lymphoma, Large B-Cell, Diffuse - microbiology Lymphoma, Non-Hodgkin - microbiology Mice Polycythemia Vera - microbiology Spleen Spleen - microbiology Spleen focus forming viruses Tissue culture techniques Tissue Extracts Virus Cultivation Viruses |
| title | Helper Activity of Human Leukemic Tissue Extracts for Leukemia Virus Expression in Mice |
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