Promoter DNA methylation regulates progranulin expression and is altered in FTLD

Frontotemporal lobar degeneration (FTLD) is a heterogeneous group of neurodegenerative diseases associated with personality changes and progressive dementia. Loss-of-function mutations in the growth factor progranulin (GRN) cause autosomal dominant FTLD, but so far the pathomechanism of sporadic FTL...

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Veröffentlicht in:	Acta neuropathologica communications 2013-05, Vol.1 (1), p.16-16, Article 16
Hauptverfasser:	Banzhaf-Strathmann, Julia, Claus, Rainer, Mücke, Oliver, Rentzsch, Kristin, van der Zee, Julie, Engelborghs, Sebastiaan, De Deyn, Peter P, Cruts, Marc, van Broeckhoven, Christine, Plass, Christoph, Edbauer, Dieter
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - metabolism Animals Azacitidine - analogs & derivatives Azacitidine - pharmacology Brain - metabolism Cell Line CpG Islands Development and progression DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors DNA (Cytosine-5-)-Methyltransferases - metabolism DNA Methylation Enzyme Inhibitors - pharmacology Epigenetic inheritance Female Frontotemporal dementia Frontotemporal Lobar Degeneration - genetics Frontotemporal Lobar Degeneration - metabolism Gene Expression Regulation - drug effects Gene mutations Genetic aspects Growth factors HEK293 Cells Humans Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Male Methyltransferases Mice Middle Aged Parkinson Disease - metabolism Promoter Regions, Genetic RNA, Messenger - metabolism
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