Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools

The rate of mutations in eukaryotes depends on a plethora of factors and is not immediately derived from the fidelity of DNA polymerases (Pols). Replication of chromosomes containing the anti‐parallel strands of duplex DNA occurs through the copying of leading and lagging strand templates by a trio...

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Veröffentlicht in:	Environmental and molecular mutagenesis 2012-12, Vol.53 (9), p.699-724
Hauptverfasser:	Waisertreiger, Irina S.-R., Liston, Victoria G., Menezes, Miriam R., Kim, Hyun-Min, Lobachev, Kirill S., Stepchenkova, Elena I., Tahirov, Tahir H., Rogozin, Igor B., Pavlov, Youri I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA polymerases DNA Replication DNA-Directed DNA Polymerase - metabolism Humans Mutagenesis nucleotide pools Nucleotides - metabolism Okazaki fragments
Online-Zugang:	Volltext
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