Cognitive enhancing treatment with a PPARγ agonist normalizes dentate granule cell presynaptic function in Tg2576 APP mice

Hippocampal network hyperexcitability is considered an early indicator of Alzheimer's disease (AD) memory impairment. Some AD mouse models exhibit similar network phenotypes. In this study we focused on dentate gyrus (DG) granule cell spontaneous and evoked properties in 9-month-old Tg2576 mice...

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Veröffentlicht in:	The Journal of neuroscience 2014-01, Vol.34 (3), p.1028-1036
Hauptverfasser:	Nenov, Miroslav N, Laezza, Fernanda, Haidacher, Sigmund J, Zhao, Yingxin, Sadygov, Rovshan G, Starkey, Jonathan M, Spratt, Heidi, Luxon, Bruce A, Dineley, Kelly T, Denner, Larry
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Protein Precursor - genetics Animals Dentate Gyrus - drug effects Dentate Gyrus - physiology Female Male Mice Mice, Inbred C57BL Mice, Transgenic Nootropic Agents - pharmacology Organ Culture Techniques PPAR gamma - agonists PPAR gamma - physiology Presynaptic Terminals - drug effects Presynaptic Terminals - physiology Protein Interaction Maps - drug effects Protein Interaction Maps - physiology Protein Transport - drug effects Protein Transport - physiology Thiazolidinediones - pharmacology
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