Characterization of H7N9 influenza A viruses isolated from humans

Here, biological attributes of two early human isolates of the newly emerged H7N9 influenza viruses are characterized: the potential of these viruses to infect and/or transmit within various animal models is discussed, as is their relative sensitivity to neuraminidase inhibitors and experimental pol...

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Veröffentlicht in:	Nature (London) 2013-09, Vol.501 (7468), p.551-555
Hauptverfasser:	Watanabe, Tokiko, Kiso, Maki, Fukuyama, Satoshi, Nakajima, Noriko, Imai, Masaki, Yamada, Shinya, Murakami, Shin, Yamayoshi, Seiya, Iwatsuki-Horimoto, Kiyoko, Sakoda, Yoshihiro, Takashita, Emi, McBride, Ryan, Noda, Takeshi, Hatta, Masato, Imai, Hirotaka, Zhao, Dongming, Kishida, Noriko, Shirakura, Masayuki, de Vries, Robert P., Shichinohe, Shintaro, Okamatsu, Masatoshi, Tamura, Tomokazu, Tomita, Yuriko, Fujimoto, Naomi, Goto, Kazue, Katsura, Hiroaki, Kawakami, Eiryo, Ishikawa, Izumi, Watanabe, Shinji, Ito, Mutsumi, Sakai-Tagawa, Yuko, Sugita, Yukihiko, Uraki, Ryuta, Yamaji, Reina, Eisfeld, Amie J., Zhong, Gongxun, Fan, Shufang, Ping, Jihui, Maher, Eileen A., Hanson, Anthony, Uchida, Yuko, Saito, Takehiko, Ozawa, Makoto, Neumann, Gabriele, Kida, Hiroshi, Odagiri, Takato, Paulson, James C., Hasegawa, Hideki, Tashiro, Masato, Kawaoka, Yoshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/596/1578 Analysis Animals Antiviral Agents - pharmacology Avian influenza viruses Cells, Cultured Chickens - virology Comparative analysis DNA-Directed RNA Polymerases - antagonists & inhibitors Dogs Enzyme Inhibitors - pharmacology Female Ferrets - virology Genetic aspects Humanities and Social Sciences Humans Identification and classification Influenza A virus - chemistry Influenza A virus - drug effects Influenza A virus - isolation & purification Influenza A virus - pathogenicity Influenza A Virus, H1N1 Subtype - drug effects Influenza A Virus, H1N1 Subtype - enzymology Influenza viruses Influenza, Human - drug therapy Influenza, Human - virology letter Macaca fascicularis - virology Madin Darby Canine Kidney Cells Male Mice Mice, Inbred BALB C Models, Molecular Monkey Diseases - pathology Monkey Diseases - virology multidisciplinary Neuraminidase - antagonists & inhibitors Neuraminidase inhibitors Orthomyxoviridae Infections - pathology Orthomyxoviridae Infections - transmission Orthomyxoviridae Infections - virology Pathology Patient outcomes Physiological aspects Quail - virology Science Swine - virology Swine, Miniature - virology Virus Replication - drug effects Zoonoses
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