A Biodistribution and Toxicity Study of Cobalt Dichloride- N -Acetyl Cysteine in an Implantable MRI Marker for Prostate Cancer Treatment

Purpose C4, a cobalt dichloride- N -acetyl cysteine complex, is being developed as a positive-signal magnetic resonance imaging (MRI) marker to localize implanted radioactive seeds in prostate brachytherapy. We evaluated the toxicity and biodistribution of C4 in rats with the goal of simulating the...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2013-03, Vol.85 (4), p.1024-1030
Hauptverfasser:	Frank, Steven J., MD, Johansen, Mary J., PharmD, Martirosyan, Karen S., PhD, Gagea, Mihai, DVSc, Van Pelt, Carolyn S., DVM, PhD, Borne, Agatha, DVM, PhD, Carmazzi, Yudith, MS, Madden, Timothy, PharmD
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - analogs & derivatives Acetylcysteine - pharmacokinetics Acetylcysteine - toxicity ANIMAL TISSUES Animals BRACHYTHERAPY Brachytherapy - methods COBALT CONCENTRATION RATIO CYSTEINE DISEASE INCIDENCE EXCRETION FECES Hematology, Oncology and Palliative Medicine Humans IMPLANTS Kidney - metabolism KIDNEYS LIVER Liver - metabolism Magnetic Resonance Imaging - methods Male MORTALITY NEOPLASMS NMR IMAGING PROSTATE Prostate - metabolism Prostatic Neoplasms - radiotherapy Radiology RADIOLOGY AND NUCLEAR MEDICINE RATS SURGERY Tissue Distribution TOXICITY URINE
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