Epidermal Snail expression drives skin cancer initiation and progression through enhanced cytoprotection, epidermal stem/progenitor cell expansion and enhanced metastatic potential

Expression of the EMT-inducing transcription factor Snail is enhanced in different human cancers. To investigate the in vivo role of Snail during progression of epithelial cancer, we used a mouse model with skin-specific overexpression of Snail. Snail transgenic mice spontaneously developed distinct...

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Veröffentlicht in:	Cell death and differentiation 2014-02, Vol.21 (2), p.310-320
Hauptverfasser:	De Craene, B, Denecker, G, Vermassen, P, Taminau, J, Mauch, C, Derore, A, Jonkers, J, Fuchs, E, Berx, G
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/142 631/67/1813 631/67/322 692/420/755 Animals Apoptosis Biochemistry Biomedical and Life Sciences Breast cancer Cell Biology Cell Cycle Analysis Cell death Cell Differentiation Cell Proliferation Disease Progression Humans Life Sciences Medical prognosis Metastasis Mice Mice, Transgenic Molecular biology Neoplasm Metastasis - genetics Neoplasm Metastasis - pathology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Oncology Original Paper Sebaceous Gland Neoplasms - genetics Sebaceous Gland Neoplasms - pathology Skin cancer Skin Neoplasms - genetics Skin Neoplasms - pathology Snail Family Transcription Factors Stem Cells Transcription factors Transcription Factors - genetics Transgenic animals Tumors
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