Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo

Alzheimer's disease (AD) is pathologically characterized by the deposition of extracellular amyloid-β plaques and intracellular aggregation of tau protein in neurofibrillary tangles (NFTs) (1, 2). Progression of NFT pathology is closely correlated with both increased neurodegeneration and cogni...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-01, Vol.111 (1), p.510-514
Hauptverfasser:	Kuchibhotla, Kishore V., Wegmann, Susanne, Kopeikina, Katherine J., Hawkes, Jonathan, Rudinskiy, Nikita, Andermann, Mark L., Spires-Jones, Tara L., Bacskai, Brian J., Hyman, Bradley T.
Format:	Artikel
Sprache:	eng
Schlagworte:	adults Alzheimer disease Alzheimer Disease - pathology Alzheimer's disease Alzheimers disease Animals Biological Sciences Brain Brain - pathology Calcium Calcium - metabolism Cognition & reasoning Correlation analysis cortex Dependovirus - metabolism Humans image analysis Image Processing, Computer-Assisted Imaging Mice Mice, Transgenic Microscopy, Fluorescence Models, Neurological mutants Mutation neural networks neurodegenerative diseases Neurofibrillary Tangles - metabolism Neurons Neurons - pathology Pathology Photons Proteins T tests tau Proteins - genetics tau Proteins - metabolism Tauopathies - pathology Transgenes Visual cortex Visual stimulation
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