A stem cell-like gene expression signature associates with inferior outcomes and a distinct microRNA expression profile in adults with primary cytogenetically normal acute myeloid leukemia

Acute myeloid leukemia (AML) is hypothesized to be sustained by self-renewing leukemia stem cells (LSCs). Recently, gene expression signatures (GES) from functionally defined AML LSC populations were reported, and expression of a ‘core enriched’ (CE) GES, representing 44 genes activated in LCSs, con...

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Veröffentlicht in:	Leukemia 2013-10, Vol.27 (10), p.2023-2031
Hauptverfasser:	Metzeler, K H, Maharry, K, Kohlschmidt, J, Volinia, S, Mrózek, K, Becker, H, Nicolet, D, Whitman, S P, Mendler, J H, Schwind, S, Eisfeld, A-K, Wu, Y-Z, Powell, B L, Carter, T H, Wetzler, M, Kolitz, J E, Baer, M R, Carroll, A J, Stone, R M, Caligiuri, M A, Marcucci, G, Bloomfield, C D
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/191/2018 631/337/384/331 692/699/67/1990/283/1897 692/699/67/71 Acute myeloid leukemia Adolescent Adult Aged Aged, 80 and over Biomarkers, Tumor - genetics Cancer Cancer Research Clinical trials Critical Care Medicine Cytogenetic Analysis Female Gene expression Genetic aspects Health aspects Hematology Humans Intensive Internal Medicine Kinases Leukemia Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - mortality Leukemia, Myeloid, Acute - therapy Male Medicine Medicine & Public Health MicroRNA MicroRNAs MicroRNAs - genetics Middle Aged miRNA Mutation Oligonucleotide Array Sequence Analysis Oncology original-article Patients Physiological aspects Prognosis Remission Remission (Medicine) Remission Induction Ribonucleic acid RNA RNA sequencing Runx1 protein Stem cells Stem Cells - metabolism Stem Cells - pathology Survival Survival Rate Transcriptome Young Adult
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