Vascular Burden and Cognitive Functioning in Depressed Older Adults
Background Vascular burden is known to contribute to geriatric depression and cognitive impairment. The objective of our study was to evaluate the relationship between vascular burden and pattern of cognitive impairment in older adults with depression. Methods Ninety-four community-dwelling older ad...
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| Veröffentlicht in: | The American journal of geriatric psychiatry 2012-08, Vol.20 (8), p.673-681 |
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| container_title | The American journal of geriatric psychiatry |
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| creator | Schneider, Brooke, Ph.D Ercoli, Linda, Ph.D Siddarth, Prabha, Ph.D Lavretsky, Helen, M.D., M.S |
| description | Background Vascular burden is known to contribute to geriatric depression and cognitive impairment. The objective of our study was to evaluate the relationship between vascular burden and pattern of cognitive impairment in older adults with depression. Methods Ninety-four community-dwelling older adults (mean age = 70.8 years; SD = 7.63) diagnosed with major depression were recruited to participate in the tai chi complementary use study aimed to improve antidepressant response to an antidepressant medication. All participants received comprehensive evaluations of depression, apathy, and vascular risk factors, and completed a battery of cognitive measures of memory, cognitive control, verbal fluency, and attention. Results The severity of vascular burden was significantly correlated with depression severity and impaired performance on measures of cognitive control (i.e., inhibition/mental flexibility), and attention, but not memory or verbal fluency. Neither the severity of comorbid apathy nor medical illness burden was related to cognitive impairment. Conclusions Vascular burden in older depressed adults contributes to cognitive impairment, particularly in domains of attention and cognitive control. Our findings suggest that aggressive treatment of vascular risk factors may reduce risk for further cognitive decline in depressed older adults. |
| doi_str_mv | 10.1097/JGP.0b013e31822ccd64 |
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The objective of our study was to evaluate the relationship between vascular burden and pattern of cognitive impairment in older adults with depression. Methods Ninety-four community-dwelling older adults (mean age = 70.8 years; SD = 7.63) diagnosed with major depression were recruited to participate in the tai chi complementary use study aimed to improve antidepressant response to an antidepressant medication. All participants received comprehensive evaluations of depression, apathy, and vascular risk factors, and completed a battery of cognitive measures of memory, cognitive control, verbal fluency, and attention. Results The severity of vascular burden was significantly correlated with depression severity and impaired performance on measures of cognitive control (i.e., inhibition/mental flexibility), and attention, but not memory or verbal fluency. Neither the severity of comorbid apathy nor medical illness burden was related to cognitive impairment. Conclusions Vascular burden in older depressed adults contributes to cognitive impairment, particularly in domains of attention and cognitive control. Our findings suggest that aggressive treatment of vascular risk factors may reduce risk for further cognitive decline in depressed older adults.</description><identifier>ISSN: 1064-7481</identifier><identifier>EISSN: 1545-7214</identifier><identifier>DOI: 10.1097/JGP.0b013e31822ccd64</identifier><identifier>PMID: 21857219</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Aged ; Apathy ; Cerebrovascular risk factors ; Cognition Disorders - complications ; cognitive impairment ; Depression - complications ; Female ; geriatric depression ; Humans ; Internal Medicine ; Male ; Middle Aged ; Risk Factors ; Severity of Illness Index ; vascular disease ; Vascular Diseases - complications</subject><ispartof>The American journal of geriatric psychiatry, 2012-08, Vol.20 (8), p.673-681</ispartof><rights>American Association for Geriatric Psychiatry</rights><rights>2012 American Association for Geriatric Psychiatry</rights><rights>Copyright Lippincott Williams & Wilkins Aug 2012</rights><rights>2011 American Association for Geriatric Psychiatry 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c546t-d43036c6eb9ed7cd6d2fd493d175c662ade105226ee92775fc47d2fae29c51bd3</citedby><cites>FETCH-LOGICAL-c546t-d43036c6eb9ed7cd6d2fd493d175c662ade105226ee92775fc47d2fae29c51bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1030747928?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,64385,64387,64389,72341</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21857219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schneider, Brooke, Ph.D</creatorcontrib><creatorcontrib>Ercoli, Linda, Ph.D</creatorcontrib><creatorcontrib>Siddarth, Prabha, Ph.D</creatorcontrib><creatorcontrib>Lavretsky, Helen, M.D., M.S</creatorcontrib><title>Vascular Burden and Cognitive Functioning in Depressed Older Adults</title><title>The American journal of geriatric psychiatry</title><addtitle>Am J Geriatr Psychiatry</addtitle><description>Background Vascular burden is known to contribute to geriatric depression and cognitive impairment. The objective of our study was to evaluate the relationship between vascular burden and pattern of cognitive impairment in older adults with depression. Methods Ninety-four community-dwelling older adults (mean age = 70.8 years; SD = 7.63) diagnosed with major depression were recruited to participate in the tai chi complementary use study aimed to improve antidepressant response to an antidepressant medication. All participants received comprehensive evaluations of depression, apathy, and vascular risk factors, and completed a battery of cognitive measures of memory, cognitive control, verbal fluency, and attention. Results The severity of vascular burden was significantly correlated with depression severity and impaired performance on measures of cognitive control (i.e., inhibition/mental flexibility), and attention, but not memory or verbal fluency. Neither the severity of comorbid apathy nor medical illness burden was related to cognitive impairment. Conclusions Vascular burden in older depressed adults contributes to cognitive impairment, particularly in domains of attention and cognitive control. Our findings suggest that aggressive treatment of vascular risk factors may reduce risk for further cognitive decline in depressed older adults.</description><subject>Aged</subject><subject>Apathy</subject><subject>Cerebrovascular risk factors</subject><subject>Cognition Disorders - complications</subject><subject>cognitive impairment</subject><subject>Depression - complications</subject><subject>Female</subject><subject>geriatric depression</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>vascular disease</subject><subject>Vascular Diseases - complications</subject><issn>1064-7481</issn><issn>1545-7214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkk9PVDEUxRujEUS_gTEvccPmYf_3dWOCg4CGBBPBbdNp74zFTju2703Ct6cTEHQ2rtqkv3t6zz0XobcEHxGs1YevZ9-O8BwTBowMlDrnJX-G9ongoleU8OftjiXvFR_IHnpV6w3GWGrJX6I9SgbRGL2PZj9sdVO0pfs0FQ-ps8l3s7xMYQwb6E6n5MaQU0jLLqTuBNYFagXfXUYPpTv2Uxzra_RiYWOFNw_nAbo-_Xw1O-8vLs--zI4veie4HHvPGWbSSZhr8Kq16-nCc808UcJJSa0HggWlEkBTpcTCcdUQC1Q7QeaeHaCP97rrab4C7yCNxUazLmFly63JNph_X1L4aZZ5Y9gw6EHoJnD4IFDy7wnqaFahOojRJshTNQRTNTAhuWro-x30Jk8lNXuNYlhxpenQKH5PuZJrLbB4bIZgs03JtJTMbkqt7N3fRh6L_sTy5BTaODcBiqkuQHLgQwE3Gp_D_37YFXAxpOBs_AW3UJ-8mEoNNt-3m7JdFEIlxYppdgcS4bi8</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>Schneider, Brooke, Ph.D</creator><creator>Ercoli, Linda, Ph.D</creator><creator>Siddarth, Prabha, Ph.D</creator><creator>Lavretsky, Helen, M.D., M.S</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>4T-</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2R</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120801</creationdate><title>Vascular Burden and Cognitive Functioning in Depressed Older Adults</title><author>Schneider, Brooke, Ph.D ; Ercoli, Linda, Ph.D ; Siddarth, Prabha, Ph.D ; Lavretsky, Helen, M.D., M.S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c546t-d43036c6eb9ed7cd6d2fd493d175c662ade105226ee92775fc47d2fae29c51bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Apathy</topic><topic>Cerebrovascular risk factors</topic><topic>Cognition Disorders - complications</topic><topic>cognitive impairment</topic><topic>Depression - complications</topic><topic>Female</topic><topic>geriatric depression</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>vascular disease</topic><topic>Vascular Diseases - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schneider, Brooke, Ph.D</creatorcontrib><creatorcontrib>Ercoli, Linda, Ph.D</creatorcontrib><creatorcontrib>Siddarth, Prabha, Ph.D</creatorcontrib><creatorcontrib>Lavretsky, Helen, M.D., M.S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection【Remote access available】</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Social Science Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database (ProQuest)</collection><collection>Social Science Database (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schneider, Brooke, Ph.D</au><au>Ercoli, Linda, Ph.D</au><au>Siddarth, Prabha, Ph.D</au><au>Lavretsky, Helen, M.D., M.S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vascular Burden and Cognitive Functioning in Depressed Older Adults</atitle><jtitle>The American journal of geriatric psychiatry</jtitle><addtitle>Am J Geriatr Psychiatry</addtitle><date>2012-08-01</date><risdate>2012</risdate><volume>20</volume><issue>8</issue><spage>673</spage><epage>681</epage><pages>673-681</pages><issn>1064-7481</issn><eissn>1545-7214</eissn><abstract>Background Vascular burden is known to contribute to geriatric depression and cognitive impairment. The objective of our study was to evaluate the relationship between vascular burden and pattern of cognitive impairment in older adults with depression. Methods Ninety-four community-dwelling older adults (mean age = 70.8 years; SD = 7.63) diagnosed with major depression were recruited to participate in the tai chi complementary use study aimed to improve antidepressant response to an antidepressant medication. All participants received comprehensive evaluations of depression, apathy, and vascular risk factors, and completed a battery of cognitive measures of memory, cognitive control, verbal fluency, and attention. Results The severity of vascular burden was significantly correlated with depression severity and impaired performance on measures of cognitive control (i.e., inhibition/mental flexibility), and attention, but not memory or verbal fluency. Neither the severity of comorbid apathy nor medical illness burden was related to cognitive impairment. Conclusions Vascular burden in older depressed adults contributes to cognitive impairment, particularly in domains of attention and cognitive control. Our findings suggest that aggressive treatment of vascular risk factors may reduce risk for further cognitive decline in depressed older adults.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>21857219</pmid><doi>10.1097/JGP.0b013e31822ccd64</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The American journal of geriatric psychiatry, 2012-08, Vol.20 (8), p.673-681 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; ProQuest Central |
| subjects | Aged Apathy Cerebrovascular risk factors Cognition Disorders - complications cognitive impairment Depression - complications Female geriatric depression Humans Internal Medicine Male Middle Aged Risk Factors Severity of Illness Index vascular disease Vascular Diseases - complications |
| title | Vascular Burden and Cognitive Functioning in Depressed Older Adults |
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