Endurance Training Increases Leptin Expression in the Retroperitoneal Adipose Tissue of Rats Fed with a High-Sugar Diet
The presence of leptin receptors in white adipose tissue (WAT) suggests a type of peripheral control during the development of obesity and other metabolic disorders. Both diet composition and exercise influence serum leptin; however, the effect of their combination on long-term WAT leptin metabolism...
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| Veröffentlicht in: | Lipids 2014-01, Vol.49 (1), p.85-96 |
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| creator | de Queiroz, Karina Barbosa Guimarães, Juliana Bohnen Coimbra, Cândido Celso Rodovalho, Gisele Vieira Carneiro, Cláudia Martins Evangelista, Elísio Alberto Guerra-Sá, Renata |
| description | The presence of leptin receptors in white adipose tissue (WAT) suggests a type of peripheral control during the development of obesity and other metabolic disorders. Both diet composition and exercise influence serum leptin; however, the effect of their combination on long-term WAT leptin metabolism is unknown. In this study, rats fed with standard or high-sugar diets (HSD) were simultaneously subjected to running training for 4- and 8-week periods, and the retroperitoneal WAT (rWAT) was evaluated for adipocyte cell size, lipid and catecholamine content,
Lep
,
OB
-
Rb
and
Ucp2
mRNA transcription levels, and circulating leptin and non-esterified fatty acids (NEFA). The HSD groups displayed a higher adiposity index and rWAT weight,
Lep
mRNA and protein upregulation, and a period-dependent effect on
OB
-
Rb
mRNA expression. Exercise decreased serum leptin and upregulated the
OB
-
Rb
mRNA levels. However, in rats fed with an HSD, the increase in
OB
-
Rb
mRNA and reduction in catecholamine levels resulted in a high level of adiposity and hyperleptinemia. The combination of training and an HSD decreases the NEFA levels and upregulating the
Ucp2
mRNA expression in the 4-week period, while downregulating the
Ucp2
mRNA expression in the 8-week period without changing the NEFA levels. Our results suggest that an HSD induces an increase in leptin expression in rWAT, while reducing adipocytes via leptin-mediated lipolysis after an 8-week period. In exercised rats fed an HSD, TAG synthesis and storage overlaps with lipolysis, promoting fat store development and
Lep
mRNA and plasma protein upregulation in adult rats. |
| doi_str_mv | 10.1007/s11745-013-3854-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3889676</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3171711651</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5185-153ab9b16bc3aa08d94b24b39771fe9a6c80080eb8185dc0f421084de1cfd6293</originalsourceid><addsrcrecordid>eNqFkV9rFDEUxYModlv9AL5IwOep-TeT5EUo7dYuLCi1PodM5s5syjYZkxnXfntTppb6ID6FS84593B_CL2j5JQSIj9mSqWoK0J5xVUtKvkCrWhdq0pzIl-iFSFMVIIReoSOc74tIxW6fo2OmGCCE0JW6LAO3ZxscIBvkvXBhwFvgktgM2S8hXHyAa9_jQly9jHgMk07wNcwpThC8lMMYPf4rPNjzCXD5zwDjj2-tlPGl9Dhg5922OIrP-yqb_NgE77wML1Br3q7z_D28T1B3y_XN-dX1fbL58352bZyNVV1RWtuW93SpnXcWqI6LVomWq6lpD1o2zhFiCLQqqLuHOkFo0SJDqjru4ZpfoI-Lbnj3N5B5yBMye7NmPydTfcmWm_-_gl-Z4b403CldCObEvDhMSDFHzPkydzGOYXS2VAheaMVU7So6KJyKeacoH_aQIl5YGUWVqawMg-sjCye98-rPTn-wCkCuQgOfg_3_080283Xi3KOujjZ4szFFAZIz0r_s89v_0qw2Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1473698281</pqid></control><display><type>article</type><title>Endurance Training Increases Leptin Expression in the Retroperitoneal Adipose Tissue of Rats Fed with a High-Sugar Diet</title><source>MEDLINE</source><source>SpringerNature Journals</source><source>Access via Wiley Online Library</source><creator>de Queiroz, Karina Barbosa ; Guimarães, Juliana Bohnen ; Coimbra, Cândido Celso ; Rodovalho, Gisele Vieira ; Carneiro, Cláudia Martins ; Evangelista, Elísio Alberto ; Guerra-Sá, Renata</creator><creatorcontrib>de Queiroz, Karina Barbosa ; Guimarães, Juliana Bohnen ; Coimbra, Cândido Celso ; Rodovalho, Gisele Vieira ; Carneiro, Cláudia Martins ; Evangelista, Elísio Alberto ; Guerra-Sá, Renata</creatorcontrib><description>The presence of leptin receptors in white adipose tissue (WAT) suggests a type of peripheral control during the development of obesity and other metabolic disorders. Both diet composition and exercise influence serum leptin; however, the effect of their combination on long-term WAT leptin metabolism is unknown. In this study, rats fed with standard or high-sugar diets (HSD) were simultaneously subjected to running training for 4- and 8-week periods, and the retroperitoneal WAT (rWAT) was evaluated for adipocyte cell size, lipid and catecholamine content,
Lep
,
OB
-
Rb
and
Ucp2
mRNA transcription levels, and circulating leptin and non-esterified fatty acids (NEFA). The HSD groups displayed a higher adiposity index and rWAT weight,
Lep
mRNA and protein upregulation, and a period-dependent effect on
OB
-
Rb
mRNA expression. Exercise decreased serum leptin and upregulated the
OB
-
Rb
mRNA levels. However, in rats fed with an HSD, the increase in
OB
-
Rb
mRNA and reduction in catecholamine levels resulted in a high level of adiposity and hyperleptinemia. The combination of training and an HSD decreases the NEFA levels and upregulating the
Ucp2
mRNA expression in the 4-week period, while downregulating the
Ucp2
mRNA expression in the 8-week period without changing the NEFA levels. Our results suggest that an HSD induces an increase in leptin expression in rWAT, while reducing adipocytes via leptin-mediated lipolysis after an 8-week period. In exercised rats fed an HSD, TAG synthesis and storage overlaps with lipolysis, promoting fat store development and
Lep
mRNA and plasma protein upregulation in adult rats.</description><identifier>ISSN: 0024-4201</identifier><identifier>EISSN: 1558-9307</identifier><identifier>DOI: 10.1007/s11745-013-3854-7</identifier><identifier>PMID: 24243000</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adipocytes - cytology ; Adipocytes - drug effects ; Adipocytes - metabolism ; Adipose tissue ; Animal tissues ; Animals ; Biomedical and Life Sciences ; Body fat ; Catecholamines - metabolism ; Cell Size - drug effects ; Chronic exercise ; Diet ; Dietary Carbohydrates - administration & dosage ; Dietary Carbohydrates - pharmacology ; Fatty Acids, Nonesterified - blood ; Fatty Acids, Nonesterified - metabolism ; Gene Expression - drug effects ; High‐sugar diet ; Intra-Abdominal Fat - cytology ; Intra-Abdominal Fat - drug effects ; Intra-Abdominal Fat - metabolism ; Ion Channels - genetics ; Ion Channels - metabolism ; Leptin - blood ; Leptin - genetics ; Leptin - metabolism ; Leptin expression ; Life Sciences ; Lipidology ; Lipids ; Lipids - analysis ; Lipolysis - drug effects ; Male ; Medical Biochemistry ; Medicinal Chemistry ; Metabolic disorders ; Metabolism ; Microbial Genetics and Genomics ; Mitochondrial Proteins - genetics ; Mitochondrial Proteins - metabolism ; Neurochemistry ; Nutrition ; Obesity ; Original ; Original Article ; Physical Conditioning, Animal ; Radioimmunoassay ; Rats ; Rats, Wistar ; Receptors, Leptin - genetics ; Receptors, Leptin - metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Sugar ; Time Factors ; Training ; Uncoupling Protein 2</subject><ispartof>Lipids, 2014-01, Vol.49 (1), p.85-96</ispartof><rights>The Author(s) 2013</rights><rights>2014 American Oil Chemists' Society (AOCS)</rights><rights>AOCS 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5185-153ab9b16bc3aa08d94b24b39771fe9a6c80080eb8185dc0f421084de1cfd6293</citedby><cites>FETCH-LOGICAL-c5185-153ab9b16bc3aa08d94b24b39771fe9a6c80080eb8185dc0f421084de1cfd6293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11745-013-3854-7$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11745-013-3854-7$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,41488,42557,45574,45575,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24243000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Queiroz, Karina Barbosa</creatorcontrib><creatorcontrib>Guimarães, Juliana Bohnen</creatorcontrib><creatorcontrib>Coimbra, Cândido Celso</creatorcontrib><creatorcontrib>Rodovalho, Gisele Vieira</creatorcontrib><creatorcontrib>Carneiro, Cláudia Martins</creatorcontrib><creatorcontrib>Evangelista, Elísio Alberto</creatorcontrib><creatorcontrib>Guerra-Sá, Renata</creatorcontrib><title>Endurance Training Increases Leptin Expression in the Retroperitoneal Adipose Tissue of Rats Fed with a High-Sugar Diet</title><title>Lipids</title><addtitle>Lipids</addtitle><addtitle>Lipids</addtitle><description>The presence of leptin receptors in white adipose tissue (WAT) suggests a type of peripheral control during the development of obesity and other metabolic disorders. Both diet composition and exercise influence serum leptin; however, the effect of their combination on long-term WAT leptin metabolism is unknown. In this study, rats fed with standard or high-sugar diets (HSD) were simultaneously subjected to running training for 4- and 8-week periods, and the retroperitoneal WAT (rWAT) was evaluated for adipocyte cell size, lipid and catecholamine content,
Lep
,
OB
-
Rb
and
Ucp2
mRNA transcription levels, and circulating leptin and non-esterified fatty acids (NEFA). The HSD groups displayed a higher adiposity index and rWAT weight,
Lep
mRNA and protein upregulation, and a period-dependent effect on
OB
-
Rb
mRNA expression. Exercise decreased serum leptin and upregulated the
OB
-
Rb
mRNA levels. However, in rats fed with an HSD, the increase in
OB
-
Rb
mRNA and reduction in catecholamine levels resulted in a high level of adiposity and hyperleptinemia. The combination of training and an HSD decreases the NEFA levels and upregulating the
Ucp2
mRNA expression in the 4-week period, while downregulating the
Ucp2
mRNA expression in the 8-week period without changing the NEFA levels. Our results suggest that an HSD induces an increase in leptin expression in rWAT, while reducing adipocytes via leptin-mediated lipolysis after an 8-week period. In exercised rats fed an HSD, TAG synthesis and storage overlaps with lipolysis, promoting fat store development and
Lep
mRNA and plasma protein upregulation in adult rats.</description><subject>Adipocytes - cytology</subject><subject>Adipocytes - drug effects</subject><subject>Adipocytes - metabolism</subject><subject>Adipose tissue</subject><subject>Animal tissues</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Body fat</subject><subject>Catecholamines - metabolism</subject><subject>Cell Size - drug effects</subject><subject>Chronic exercise</subject><subject>Diet</subject><subject>Dietary Carbohydrates - administration & dosage</subject><subject>Dietary Carbohydrates - pharmacology</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Fatty Acids, Nonesterified - metabolism</subject><subject>Gene Expression - drug effects</subject><subject>High‐sugar diet</subject><subject>Intra-Abdominal Fat - cytology</subject><subject>Intra-Abdominal Fat - drug effects</subject><subject>Intra-Abdominal Fat - metabolism</subject><subject>Ion Channels - genetics</subject><subject>Ion Channels - metabolism</subject><subject>Leptin - blood</subject><subject>Leptin - genetics</subject><subject>Leptin - metabolism</subject><subject>Leptin expression</subject><subject>Life Sciences</subject><subject>Lipidology</subject><subject>Lipids</subject><subject>Lipids - analysis</subject><subject>Lipolysis - drug effects</subject><subject>Male</subject><subject>Medical Biochemistry</subject><subject>Medicinal Chemistry</subject><subject>Metabolic disorders</subject><subject>Metabolism</subject><subject>Microbial Genetics and Genomics</subject><subject>Mitochondrial Proteins - genetics</subject><subject>Mitochondrial Proteins - metabolism</subject><subject>Neurochemistry</subject><subject>Nutrition</subject><subject>Obesity</subject><subject>Original</subject><subject>Original Article</subject><subject>Physical Conditioning, Animal</subject><subject>Radioimmunoassay</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Leptin - genetics</subject><subject>Receptors, Leptin - metabolism</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Sugar</subject><subject>Time Factors</subject><subject>Training</subject><subject>Uncoupling Protein 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Training Increases Leptin Expression in the Retroperitoneal Adipose Tissue of Rats Fed with a High-Sugar Diet</title><author>de Queiroz, Karina Barbosa ; Guimarães, Juliana Bohnen ; Coimbra, Cândido Celso ; Rodovalho, Gisele Vieira ; Carneiro, Cláudia Martins ; Evangelista, Elísio Alberto ; Guerra-Sá, Renata</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5185-153ab9b16bc3aa08d94b24b39771fe9a6c80080eb8185dc0f421084de1cfd6293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adipocytes - cytology</topic><topic>Adipocytes - drug effects</topic><topic>Adipocytes - metabolism</topic><topic>Adipose tissue</topic><topic>Animal tissues</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Body fat</topic><topic>Catecholamines - metabolism</topic><topic>Cell Size - drug effects</topic><topic>Chronic exercise</topic><topic>Diet</topic><topic>Dietary Carbohydrates - administration & dosage</topic><topic>Dietary Carbohydrates - pharmacology</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Fatty Acids, Nonesterified - metabolism</topic><topic>Gene Expression - drug effects</topic><topic>High‐sugar diet</topic><topic>Intra-Abdominal Fat - cytology</topic><topic>Intra-Abdominal Fat - drug effects</topic><topic>Intra-Abdominal Fat - metabolism</topic><topic>Ion Channels - genetics</topic><topic>Ion Channels - metabolism</topic><topic>Leptin - blood</topic><topic>Leptin - genetics</topic><topic>Leptin - metabolism</topic><topic>Leptin expression</topic><topic>Life Sciences</topic><topic>Lipidology</topic><topic>Lipids</topic><topic>Lipids - analysis</topic><topic>Lipolysis - drug effects</topic><topic>Male</topic><topic>Medical Biochemistry</topic><topic>Medicinal Chemistry</topic><topic>Metabolic disorders</topic><topic>Metabolism</topic><topic>Microbial Genetics and Genomics</topic><topic>Mitochondrial Proteins - genetics</topic><topic>Mitochondrial Proteins - metabolism</topic><topic>Neurochemistry</topic><topic>Nutrition</topic><topic>Obesity</topic><topic>Original</topic><topic>Original Article</topic><topic>Physical Conditioning, Animal</topic><topic>Radioimmunoassay</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Leptin - genetics</topic><topic>Receptors, Leptin - metabolism</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Sugar</topic><topic>Time Factors</topic><topic>Training</topic><topic>Uncoupling Protein 2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Queiroz, Karina Barbosa</creatorcontrib><creatorcontrib>Guimarães, Juliana Bohnen</creatorcontrib><creatorcontrib>Coimbra, Cândido Celso</creatorcontrib><creatorcontrib>Rodovalho, Gisele Vieira</creatorcontrib><creatorcontrib>Carneiro, Cláudia Martins</creatorcontrib><creatorcontrib>Evangelista, Elísio 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Diet</atitle><jtitle>Lipids</jtitle><stitle>Lipids</stitle><addtitle>Lipids</addtitle><date>2014-01</date><risdate>2014</risdate><volume>49</volume><issue>1</issue><spage>85</spage><epage>96</epage><pages>85-96</pages><issn>0024-4201</issn><eissn>1558-9307</eissn><abstract>The presence of leptin receptors in white adipose tissue (WAT) suggests a type of peripheral control during the development of obesity and other metabolic disorders. Both diet composition and exercise influence serum leptin; however, the effect of their combination on long-term WAT leptin metabolism is unknown. In this study, rats fed with standard or high-sugar diets (HSD) were simultaneously subjected to running training for 4- and 8-week periods, and the retroperitoneal WAT (rWAT) was evaluated for adipocyte cell size, lipid and catecholamine content,
Lep
,
OB
-
Rb
and
Ucp2
mRNA transcription levels, and circulating leptin and non-esterified fatty acids (NEFA). The HSD groups displayed a higher adiposity index and rWAT weight,
Lep
mRNA and protein upregulation, and a period-dependent effect on
OB
-
Rb
mRNA expression. Exercise decreased serum leptin and upregulated the
OB
-
Rb
mRNA levels. However, in rats fed with an HSD, the increase in
OB
-
Rb
mRNA and reduction in catecholamine levels resulted in a high level of adiposity and hyperleptinemia. The combination of training and an HSD decreases the NEFA levels and upregulating the
Ucp2
mRNA expression in the 4-week period, while downregulating the
Ucp2
mRNA expression in the 8-week period without changing the NEFA levels. Our results suggest that an HSD induces an increase in leptin expression in rWAT, while reducing adipocytes via leptin-mediated lipolysis after an 8-week period. In exercised rats fed an HSD, TAG synthesis and storage overlaps with lipolysis, promoting fat store development and
Lep
mRNA and plasma protein upregulation in adult rats.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24243000</pmid><doi>10.1007/s11745-013-3854-7</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0024-4201 |
| ispartof | Lipids, 2014-01, Vol.49 (1), p.85-96 |
| issn | 0024-4201 1558-9307 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3889676 |
| source | MEDLINE; SpringerNature Journals; Access via Wiley Online Library |
| subjects | Adipocytes - cytology Adipocytes - drug effects Adipocytes - metabolism Adipose tissue Animal tissues Animals Biomedical and Life Sciences Body fat Catecholamines - metabolism Cell Size - drug effects Chronic exercise Diet Dietary Carbohydrates - administration & dosage Dietary Carbohydrates - pharmacology Fatty Acids, Nonesterified - blood Fatty Acids, Nonesterified - metabolism Gene Expression - drug effects High‐sugar diet Intra-Abdominal Fat - cytology Intra-Abdominal Fat - drug effects Intra-Abdominal Fat - metabolism Ion Channels - genetics Ion Channels - metabolism Leptin - blood Leptin - genetics Leptin - metabolism Leptin expression Life Sciences Lipidology Lipids Lipids - analysis Lipolysis - drug effects Male Medical Biochemistry Medicinal Chemistry Metabolic disorders Metabolism Microbial Genetics and Genomics Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Neurochemistry Nutrition Obesity Original Original Article Physical Conditioning, Animal Radioimmunoassay Rats Rats, Wistar Receptors, Leptin - genetics Receptors, Leptin - metabolism Reverse Transcriptase Polymerase Chain Reaction Sugar Time Factors Training Uncoupling Protein 2 |
| title | Endurance Training Increases Leptin Expression in the Retroperitoneal Adipose Tissue of Rats Fed with a High-Sugar Diet |
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