Younger patients with chronic myeloid leukemia do well in spite of poor prognostic indicators: results from the randomized CML study IV

Since the advent of tyrosine kinase inhibitors, the impact of age on outcome of chronic myeloid leukemia (CML) patients has changed. We therefore analyzed patients from the randomized CML study IV to investigate disease manifestations and outcome in different age groups. One thousand five hundred tw...

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Veröffentlicht in:	Annals of hematology 2014-01, Vol.93 (1), p.71-80
Hauptverfasser:	Kalmanti, Lida, Saussele, Susanne, Lauseker, Michael, Proetel, Ulrike, Müller, Martin C., Hanfstein, Benjamin, Schreiber, Annette, Fabarius, Alice, Pfirrmann, Markus, Schnittger, Susanne, Dengler, Jolanta, Falge, Christiane, Kanz, Lothar, Neubauer, Andreas, Stegelmann, Frank, Pfreundschuh, Michael, Waller, Cornelius F., Spiekermann, Karsten, Krause, Stefan W., Heim, Dominik, Nerl, Christoph, Hossfeld, Dieter K., Kolb, Hans-Jochem, Hochhaus, Andreas, Hasford, Joerg, Hehlmann, Rüdiger
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Factors Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Benzamides - administration & dosage Benzamides - therapeutic use Cytarabine - administration & dosage Female Follow-Up Studies Fusion Proteins, bcr-abl - blood Fusion Proteins, bcr-abl - genetics Hematology Humans Imatinib Mesylate Interferon-alpha - administration & dosage Kaplan-Meier Estimate Karnofsky Performance Status Leukemia, Myeloid, Chronic-Phase - blood Leukemia, Myeloid, Chronic-Phase - drug therapy Leukemia, Myeloid, Chronic-Phase - genetics Leukemia, Myeloid, Chronic-Phase - mortality Male Medicine Medicine & Public Health Middle Aged Oncology Original Original Article Piperazines - administration & dosage Piperazines - therapeutic use Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - therapeutic use Pyrimidines - administration & dosage Pyrimidines - therapeutic use Randomized Controlled Trials as Topic - statistics & numerical data Risk Factors RNA, Messenger - blood RNA, Neoplasm - blood Splenomegaly - etiology Treatment Outcome Young Adult
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